探讨冠心病患者与正常对照者之间的复极储备。
Discussion on Repolarization Reserve between Patients with Coronary Heart Disease and Normal Controls.
机构信息
Department of Cardiology, Heji Hospital Affiliated to Changzhi Medical College, Changzhi, 046011 Shanxi, China.
Guizhou Medical University, Guiyang, 550025 Guizhou, China.
出版信息
Comput Math Methods Med. 2022 Aug 18;2022:7944969. doi: 10.1155/2022/7944969. eCollection 2022.
OBJECTIVE
To investigate the repolarization reserve of normal controls (NCs) and patients with coronary heart disease (CHD).
METHODS
From January 1st, 2010 to December 31st, 2018, 200 age- and gender-matched inpatients in the Second Hospital of Shanxi Medical University and Heji Hospital Affiliated to Changzhi Medical College were selected for treadmill exercise test (TET), including 67 patients in the myocardial ischemia group, 66 patients in the suspected myocardial ischemia group, and 67 patients in the normal control group. Coronary angiography (CAG) was performed on 49 of 133 patients in the myocardial ischemia group and the suspected myocardial ischemia group, and 9 positives and 40 negatives were identified. The heart rate (HR) and QT interval of TET examiners before exercise, during exercise (90 beats/min, 120 beats/min, maximum HR), and in the recovery period (1 minute and 3 minutes after exercise) were reviewed, and QTc values were calculated after being corrected by BaZett's.
RESULTS
The mean QTc values in NCs were all below 452 ms, before exercise, during exercise (90 beats/min, 120 beats/min and maximum HR), and during the recovery period (1 minute and 3 minutes after exercise). The comparison results of the RR interval between the two groups revealed > 0.05, indicating no statistical significance. Significant differences were present when comparing the QT intervals when the HRs were 90 beats/minute and 120 beats/minute during exercise ( < 0.05). And comparing the QTc values, it was found that the QTc values during different exercise periods were statistically different between groups ( < 0.05).
CONCLUSIONS
NCs have good repolarization reserve. CAG can confirm true myocardial ischemia patients (i.e., patients with CHD) among myocardial ischemia and suspected myocardial ischemia patients screened by TET. Patients with positive CAG have poor repolarization reserve as QT interval represents ventricular repolarization adaptability.
目的
探讨正常对照者（NCs）和冠心病（CHD）患者的复极储备。
方法
选取 2010 年 1 月 1 日至 2018 年 12 月 31 日山西医科大学第二医院和长治医学院附属和济医院 200 例年龄和性别匹配的住院患者进行平板运动试验（TET），包括心肌缺血组 67 例、疑似心肌缺血组 66 例和正常对照组 67 例。对心肌缺血组和疑似心肌缺血组的 133 例患者中的 49 例行冠状动脉造影（CAG），共检出阳性 9 例，阴性 40 例。回顾分析 TET 检查者运动前、运动中（90 次/分、120 次/分、最大心率）和恢复期（运动后 1 分钟和 3 分钟）的心率（HR）和 QT 间期，并校正 BaZett 后计算 QTc 值。
结果
NCs 的平均 QTc 值均低于 452 ms，包括运动前、运动中（90 次/分、120 次/分和最大心率）和恢复期（运动后 1 分钟和 3 分钟）。两组 RR 间期比较， > 0.05，差异无统计学意义。运动时 HR 为 90 次/分和 120 次/分时 QT 间期比较，差异有统计学意义（ < 0.05）。比较 QTc 值，发现不同运动期 QTc 值组间差异有统计学意义（ < 0.05）。
结论
NCs 有良好的复极储备。CAG 可确认 TET 筛查出的心肌缺血和疑似心肌缺血患者中真正的心肌缺血患者（即 CHD 患者）。CAG 阳性患者的复极储备较差，因为 QT 间期代表心室复极的适应性。
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