Sun Limei, Yan Wenjia, Huang Li, Li Songshan, Liu Jia, Lu Yamei, Su Manxiang, Li Zhan, Ding Xiaoyan
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, China.
Front Med (Lausanne). 2022 Aug 10;9:914207. doi: 10.3389/fmed.2022.914207. eCollection 2022.
Retinopathy of prematurity (ROP) like retinopathy (ROPLR) could occur in full/near-term newborns. The causes and clinical features are still largely elusive. This study focused on the risk factors, clinical and genetic characteristics, treatment and outcome, and prognosis of ROPLR.
A total of 47 consecutive full/near-term newborns during 2016-2017 with ROPLR were included. The clinical and genetic characteristics, treatment and outcome, prognosis, and potential underlying etiology of ROPLR were were analyzed.
91 eyes of 47 infants were found to have ROPLR. The ROPLR regressed completely in 65.9% and partially in 20.9% of eyes without any interventions. Retinal changes of family exudative vitreoretinopathy (FEVR) were allocated in 12 neonates (group A), perinatal hypoxia-ischemia were categorized in 17 neonates (group B), and the other 18 neonates were categorized in group C. Compared to those in group B/C, infants in group A had significantly more severe retinopathy (stage 4/5, < 0.001) and more treatments ( < 0.00 risk factor 1).
Perinatal hypoxia-ischemia might be a major risk factor for ROPLR, in which spontaneous regression was common. FEVR, confirmed by positive family findings and genetic testing, might be the second risk factor of ROPLR, in which retinopathy is more severe and treatment is needed.
足月/近足月新生儿可能发生早产儿视网膜病变样视网膜病变（ROPLR）。其病因和临床特征仍大多不明。本研究聚焦于ROPLR的危险因素、临床和遗传特征、治疗及结局以及预后。
纳入2016 - 2017年间连续的47例患有ROPLR的足月/近足月新生儿。分析ROPLR的临床和遗传特征、治疗及结局、预后以及潜在的病因。
47例婴儿的91只眼被发现患有ROPLR。在未进行任何干预的情况下，65.9%的眼ROPLR完全消退，20.9%的眼部分消退。12例新生儿（A组）出现家族性渗出性玻璃体视网膜病变（FEVR）的视网膜改变，17例新生儿（B组）归类为围产期缺氧缺血，另外18例新生儿归类为C组。与B/C组相比，A组婴儿的视网膜病变明显更严重（4/5期，<0.001）且接受的治疗更多（<0.00危险因素1）。
围产期缺氧缺血可能是ROPLR的主要危险因素，其中自发消退较为常见。经家族史阳性发现和基因检测证实的FEVR可能是ROPLR的第二个危险因素，其中视网膜病变更严重且需要治疗。
