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感染性心内膜炎相关的左心室假性动脉瘤:一例尸检病例报告

Left ventricular pseudoaneurysm associated with infective endocarditis: an autopsy case report.

作者信息

Rahimi Razuin, Anuar Nur Shafaradila Shamsul, Kornain Noor Kaslina Mohd, Noor Norizal Mohd

机构信息

Department of Forensic Pathology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Shah Alam, Selangor Malaysia.

Department of Forensic Medicine, Hospital Sungai Buloh, Ministry of Health Malaysia, Sungai Buloh, Malaysia.

出版信息

Egypt J Forensic Sci. 2022;12(1):35. doi: 10.1186/s41935-022-00294-2. Epub 2022 Aug 19.

Abstract

BACKGROUND

Infective endocarditis (IE) is a bacterial infection of the heart valves or endocardium, with complications such as valve perforation, ring abscess, fistula, or damage to the subaortic structures. This case report aims to illustrate an atypical complication of IE which is a pseudoaneurysm depicting a periannular hemorrhage.

CASE PRESENTATION

We describe a case of a 19-year-old male youth who presented with fever and cough a few days prior to his demise. There was no known risk factor for IE. The autopsy revealed a bulging anterior surface, upper part of the left ventricle which was soft and slightly fluctuant. Cut section of the heart revealed large vegetations affecting the right and left coronary cusps of the aortic valve. The vegetations at the left coronary cusp were mobile, with necrotic and hollow area underneath, appearing like a cavity and containing blood clots. The course of the cavity was determined to be at the periannular region and contained within the myocardium. These findings were consistent with left ventricular pseudoaneurysm. Culture of the vegetations specimen yielded growth of sp. anti-streptolysin O titre (ASOT) was 400 IU/mL and reported as positive.

CONCLUSIONS

IE secondary to sp is rare and may result in catastrophic complications. Therefore, this case report is intended to highlight the autopsy findings of the disease as well as to create awareness of its subtle clinical symptoms.

摘要

背景

感染性心内膜炎(IE)是心脏瓣膜或心内膜的细菌感染,可引发诸如瓣膜穿孔、瓣环脓肿、瘘管或主动脉下结构损伤等并发症。本病例报告旨在阐述IE的一种非典型并发症,即表现为瓣环周围出血的假性动脉瘤。

病例介绍

我们描述了一例19岁男性青年病例,该患者在死亡前几天出现发热和咳嗽症状。无已知的IE危险因素。尸检显示左心室前表面上部膨出,质地柔软且有轻微波动感。心脏切面显示有大的赘生物累及主动脉瓣的右冠状动脉瓣叶和左冠状动脉瓣叶。左冠状动脉瓣叶上的赘生物可活动,其下方有坏死和中空区域,形似一个腔隙且含有血凝块。确定该腔隙位于瓣环区域并包含在心肌内。这些发现符合左心室假性动脉瘤。赘生物标本培养有 菌生长,抗链球菌溶血素O滴度(ASOT)为400 IU/mL,报告为阳性。

结论

菌继发的IE罕见,可能导致灾难性并发症。因此,本病例报告旨在突出该疾病的尸检结果,并提高对其细微临床症状的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7517/9390957/690097e5f362/41935_2022_294_Fig1_HTML.jpg

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