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新型冠状病毒感染康复后接种Moderna疫苗引发的重症多形红斑:病例报告及文献综述

Sever erythema multiforme post-COVID-19 moderna vaccine: Case report and literature review.

作者信息

Fadul Abdalla, Abdalla El Mustafa, Musa M, Al-Mashdali Abdulrhman, Mudathir Osman Ahmed El, Abdelmahuod Elabbass

机构信息

Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.

出版信息

Ann Med Surg (Lond). 2022 Nov;83:104461. doi: 10.1016/j.amsu.2022.104461. Epub 2022 Aug 20.

Abstract

INTRODUCTION

Although the COVID-19 Vaccine usually causes a few non-serious side effects, serious ones such as Erythema multiforme recently has been linked to it.

CASE PRESENTATION

Our patient presented with severe skin reaction one day post-Covid-19 Moderna vaccine diagnosed as erythema multiforme proven by skin biopsy that responded well to steroids.

DISCUSSION

Erythema multiform major, an immune-mediated cutaneous reaction to infections or drugs involving the oral cavity, should be considered a possible adverse effect of numerous vaccinations, including SARSCoV2. Correct patient history gathering enables early detection and successful medical therapy with oral corticosteroids.Furthermore, the disease's rarity makes establishing a causative link difficult. However, because we are still learning about the innovative antiSARSCoV2 vaccines, it is crucial to be cautious of the potential cutaneous adverse responses.

CONCLUSION

Despite being rare, life-threatening adverse reactions can occur post-COVID-19 Vaccination.

摘要

引言

尽管新冠疫苗通常会引起一些非严重的副作用,但最近严重的副作用,如多形红斑,已与其相关联。

病例介绍

我们的患者在接种新冠Moderna疫苗一天后出现严重皮肤反应,经皮肤活检诊断为多形红斑,对类固醇治疗反应良好。

讨论

重症多形红斑是一种对包括口腔在内的感染或药物的免疫介导性皮肤反应,应被视为包括新冠病毒疫苗在内的多种疫苗可能产生的不良反应。正确收集患者病史有助于早期发现并通过口服皮质类固醇成功进行药物治疗。此外,该疾病罕见,难以确定因果关系。然而,由于我们仍在了解创新的抗新冠病毒疫苗,谨慎对待潜在的皮肤不良反应至关重要。

结论

尽管罕见,但新冠疫苗接种后可能会出现危及生命的不良反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd6/9661666/a04c9f1b7e58/gr1.jpg

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