Burban Anna, Idzik Aleksandra, Gelo Agata, Filipiak Krzysztof J, Jakimowicz Tomasz, Jama Katarzyna, Grabowski Marcin, Gasecka Aleksandra, Siniarski Aleksander
Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Department of Anesthesiology and Intensive Care, Medical University of Warsaw, Warsaw, Poland.
Front Cardiovasc Med. 2022 Aug 12;9:927995. doi: 10.3389/fcvm.2022.927995. eCollection 2022.
Patients with abdominal aortic aneurysm (AAA) have a higher risk of cardiovascular (CV) events, which seems to be associated with disturbed platelet (PLT) function. Endovascular aneurysm repair (EVAR) is an emerging, less-invasive treatment alternative to surgical AAA repair. Both platelet function abnormalities in patients with AAA and the effect of EVAR on platelet function are poorly understood. In this review, we aim to fill the gap regarding the effect of EVAR on PLT function in AAA patients by discussing PLT function disturbances in patients with AAA, PLT function changes after EVAR, evidence from clinical studies regarding PLT function before and after EVAR, and antiplatelet or and antithrombotic treatment in patients undergoing EVAR. The goal of our review is to summarize the contemporary knowledge and initiate further studies to better understand PLT function changes in patients undergoing EVAR, optimize the pharmacotherapy before and after EVAR and further improve outcomes in this group of patients.
腹主动脉瘤（AAA）患者发生心血管（CV）事件的风险较高，这似乎与血小板（PLT）功能紊乱有关。血管内动脉瘤修复术（EVAR）是一种新兴的、侵入性较小的治疗方法，可替代外科AAA修复术。目前，人们对AAA患者的血小板功能异常以及EVAR对血小板功能的影响了解甚少。在本综述中，我们旨在通过讨论AAA患者的血小板功能紊乱、EVAR术后血小板功能变化、关于EVAR术前和术后血小板功能的临床研究证据以及接受EVAR治疗患者的抗血小板或抗血栓治疗，来填补关于EVAR对AAA患者血小板功能影响方面的空白。我们综述的目的是总结当代知识，并启动进一步研究，以更好地了解接受EVAR治疗患者的血小板功能变化，优化EVAR术前和术后的药物治疗，并进一步改善该组患者的治疗效果。
