Dierickx Inge, Kremer Cécile, Bruckers Liesbeth, Gyselaers Wilfried
Department of Obstetrics and Gynaecology, Sint Lucas Ziekenhuis, Gent, Belgium.
Department of Physiology, Hasselt University, Hasselt, Belgium.
Front Cardiovasc Med. 2022 Aug 12;9:911059. doi: 10.3389/fcvm.2022.911059. eCollection 2022.
This study aimed to investigate Doppler characteristics of maternal internal jugular veins in uncomplicated pregnancies vs. those affected by hypertensive disorders.
Venous pulse transit time and venous impedance index were measured at three different locations (right proximal, right distal, left proximal) of internal jugular veins according to a standardised combined Doppler-Electrocardiogram protocol in five different groups of pregnant women: uncomplicated pregnancy, early-onset preeclampsia, late-onset preeclampsia, gestational hypertension, and normotensive pregnancies with a small for gestational age foetus. Values of both parameters of the latter four groups were plotted against the reference range of uncomplicated pregnancies at corresponding gestation. Linear mixed models with random intercept were used to investigate gestational changes in venous pulse transit time and venous impedance index at the three internal jugular vein locations within and between the different groups.
A total of 127 women were included: 41 had uncomplicated pregnancies, 13 had early-onset preeclampsia, 25 had late-onset preeclampsia, 22 had gestational hypertension, and 26 had normotensive pregnancies with a small for gestational age foetus. Venous pulse transit time values were lower than uncomplicated pregnancy ( ≤ 0.001) at all three locations in the third trimester of early-onset preeclampsia.
Contrary to late-onset preeclampsia and gestational hypertension, early-onset preeclampsia is characterised by a lower venous pulse transit time at internal jugular veins compared to uncomplicated pregnancy, suggesting increased venous vascular tone.
本研究旨在调查正常妊娠与患有高血压疾病的妊娠中孕妇颈内静脉的多普勒特征。
根据标准化的多普勒 - 心电图联合方案，在五组不同的孕妇中，于颈内静脉的三个不同位置（右近端、右远端、左近端）测量静脉搏动传导时间和静脉阻抗指数，这五组孕妇分别为：正常妊娠、早发型子痫前期、晚发型子痫前期、妊娠期高血压以及胎儿小于孕周的血压正常妊娠。将后四组的这两个参数值与相应孕周正常妊娠的参考范围进行对比。使用具有随机截距的线性混合模型来研究不同组内和组间颈内静脉三个位置的静脉搏动传导时间和静脉阻抗指数的孕期变化。
共纳入127名女性：41名正常妊娠，13名早发型子痫前期，25名晚发型子痫前期，22名妊娠期高血压，26名胎儿小于孕周的血压正常妊娠。早发型子痫前期孕晚期时，在所有三个位置的静脉搏动传导时间值均低于正常妊娠（≤0.001）。
与晚发型子痫前期和妊娠期高血压相反，早发型子痫前期的特征是与正常妊娠相比，颈内静脉的静脉搏动传导时间较短，提示静脉血管张力增加。
