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生物关节修复:转化研究的成功案例。

Biologic Joint Restoration: A Translational Research Success Story.

机构信息

William and Kathryn Allen Distinguished Chair in Orthopaedic Surgery; Director, Thompson Laboratory for Regenerative Orthopaedics (TLRO) and Mizzou BioJoint® Center; and Vice Chair, Orthopaedic Research Division, University of Missouri - Columbia, Columbia, Missouri.

TLRO and Department of Orthopaedic Surgery (DOS), University of Missouri - Columbia, Columbia, Missouri.

出版信息

Mo Med. 2022 Mar-Apr;119(2):115-121.

PMID:36036037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9339389/
Abstract

Treatment options that result in consistently successful outcomes for young and active patients with joint disorders are needed. This article summarizes two decades of rigorous research using a bedside-to-bench- to-bedside translational approach based on the One Health - One Medicine concept that culminated in successful clinical use of biologic joint restoration options for treatment of knee, hip, ankle, and shoulder problems in this growing patient population.

摘要

需要为患有关节疾病的年轻且活跃的患者提供始终能取得成功结果的治疗选择。本文总结了二十年来使用基于“同一健康-同一医学”理念的床边到床边再到床边的转化研究方法进行的严格研究,最终成功将生物关节修复作为治疗这类不断增长的患者群体的膝关节、髋关节、踝关节和肩关节问题的选择。

相似文献

1
Biologic Joint Restoration: A Translational Research Success Story.生物关节修复:转化研究的成功案例。
Mo Med. 2022 Mar-Apr;119(2):115-121.
2
Biologic Joint Repair Strategies: The Mizzou BioJoint Story.生物关节修复策略:密苏里大学的生物关节故事。
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本文引用的文献

1
Outcomes Associated With Osteochondral Allograft Transplantation in Dogs.犬同种异体骨软骨移植的相关结果
Front Vet Sci. 2021 Dec 24;8:759610. doi: 10.3389/fvets.2021.759610. eCollection 2021.
2
Return to Sport After Large Single-Surface, Multisurface, or Bipolar Osteochondral Allograft Transplantation in the Knee Using Shell Grafts.使用壳状移植物进行膝关节大面积单表面、多表面或双极骨软骨异体移植后的重返运动情况
Orthop J Sports Med. 2021 Jan 22;9(1):2325967120967928. doi: 10.1177/2325967120967928. eCollection 2021 Jan.
3
Changes in knee range of motion after large osteochondral allograft transplantations.大骨软骨同种异体移植后膝关节活动范围的变化。
Knee. 2021 Jan;28:207-213. doi: 10.1016/j.knee.2020.12.004. Epub 2021 Jan 5.
4
Systematic Review of Osteochondral Allograft Transplant Immunology: How We Can Further Optimize Outcomes.系统性综述:同种异体骨软骨移植免疫:我们如何进一步优化结果。
J Knee Surg. 2021 Jan;34(1):30-38. doi: 10.1055/s-0040-1721670. Epub 2021 Jan 3.
5
Initial clinical outcomes comparing frozen versus fresh meniscus allograft transplants.比较冷冻与新鲜半月板同种异体移植的初步临床结果。
Knee. 2020 Dec;27(6):1811-1820. doi: 10.1016/j.knee.2020.09.015. Epub 2020 Nov 13.
6
Revision Total Knee Arthroplasty in Young Patients: Higher Early Reoperation and Rerevision.年轻患者的全膝关节翻修术:更高的早期再手术和再次翻修率。
J Arthroplasty. 2021 Feb;36(2):653-656. doi: 10.1016/j.arth.2020.08.052. Epub 2020 Aug 31.
7
Unicompartmental bipolar osteochondral and meniscal allograft transplantation is effective for treatment of medial compartment gonarthrosis in a canine model.单髁双极骨软骨和半月板同种异体移植治疗犬膝关节内侧间室骨关节炎模型有效。
J Orthop Res. 2021 May;39(5):1093-1102. doi: 10.1002/jor.24801. Epub 2020 Jul 27.
8
Patient-Reported Outcomes for Large Bipolar Osteochondral Allograft Transplantation in Combination with Realignment Osteotomies for the Knee.患者报告的大型双相骨软骨同种异体移植联合膝关节再排列截骨术的结果。
J Knee Surg. 2021 Sep;34(11):1260-1266. doi: 10.1055/s-0040-1710361. Epub 2020 May 5.
9
Comparison of meniscal allograft transplantation techniques using a preclinical canine model.使用临床前犬模型比较半月板同种异体移植技术。
J Orthop Res. 2021 Jan;39(1):154-164. doi: 10.1002/jor.24668. Epub 2020 Mar 31.
10
Prospective Assessment of Outcomes After Primary Unipolar, Multisurface, and Bipolar Osteochondral Allograft Transplantations in the Knee: A Comparison of 2 Preservation Methods.膝关节初次单髁、多表面和双髁骨软骨同种异体移植后结局的前瞻性评估:2 种保存方法的比较。
Am J Sports Med. 2020 May;48(6):1356-1364. doi: 10.1177/0363546520907101. Epub 2020 Mar 5.