Grice S C, Chappell E T, Prough D S, Whitley J M, Su M, Watkins W D
Stroke. 1987 Jul-Aug;18(4):787-91. doi: 10.1161/01.str.18.4.787.
In a canine model of global cerebral ischemia, 6 dogs received a saline placebo prior to the event and 5 received 12.5 mg/kg ibuprofen. Cerebral venous outflow from the confluence of the sagittal and transverse sinuses, systolic and diastolic arterial pressure, cardiac output, pH, Paco2, Pao2, and arterial and sagittal sinus thromboxane B2 and 6-keto-PGF1 alpha were measured at intervals up to 120 minutes thereafter. Postischemic cerebral hypoperfusion was significantly improved in the ibuprofen pretreatment group. Control dogs showed significant increases in sagittal sinus postischemic thromboxane B2 concentrations, but pretreated dogs showed nearly complete inhibition of postischemic thromboxane B2 production. Pretreated dogs also had significantly lower levels of 6-keto-PGF1 alpha from the sagittal sinus. There were no significant differences in the other variables at any interval. We conclude that ibuprofen ameliorates postischemic cerebral hypoperfusion, and that this improvement is associated with decreased sagittal sinus levels of thromboxane B2 and 6-keto-PGF1 alpha.
在犬全脑缺血模型中，6只犬在缺血事件发生前接受生理盐水安慰剂，5只犬接受12.5mg/kg布洛芬。此后每隔一段时间测量矢状窦和横窦汇合处的脑静脉流出量、收缩压和舒张压、心输出量、pH值、动脉血二氧化碳分压、动脉血氧分压以及动脉和矢状窦血栓素B2和6-酮-前列环素F1α。布洛芬预处理组缺血后脑灌注不足得到显著改善。对照犬矢状窦缺血后血栓素B2浓度显著升高，但预处理犬缺血后血栓素B2生成几乎完全受到抑制。预处理犬矢状窦的6-酮-前列环素F1α水平也显著降低。在任何时间段，其他变量均无显著差异。我们得出结论，布洛芬可改善缺血后脑灌注不足，且这种改善与矢状窦血栓素B2和6-酮-前列环素F1α水平降低有关。
