Sina Farzad, Najafi Darya, Aziz-Ahari Alireza, Shahraki Elham, Ahimahalle Tahere Zarouk, Namjoo Zeinab, Hassanzadeh Sajad
Skull Base Research Center, The Five Senses Institute, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran; Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran.
School of Medicine, Iran University of Medical Sciences, Tehran.
Eur J Transl Myol. 2022 Aug 12;32(3):10613. doi: 10.4081/ejtm.2022.10613.
The aim of this study was to investigate the magnetic resonance imaging (MRI) findings for the diagnose uremic encephalopathy and describe the usefulness of MRI findings in the ultimate diagnosis of uremic encephalopathy (UE). A total of 20 patients with uremic encephalopathy admitted to the hospital were evaluated in this prospective study. The clinical manifestations, laboratory and MRI imaging findings, demographic information, and clinical outcome were analyzed for each patient. We observed that the 20 prospectively reviewed patients with UE had no involvement of the basal ganglia or the lentiform fork sign (LFS). However, two-thirds of the patients had white matter involvement, and 80% of the subjects had cerebral or cortical atrophy. The arterial blood gas (ABG) analysis revealed that 50% of the patients suffered from metabolic acidosis (n=10). The results of the present study demonstrated that although the observation of Lentiform Fork Sign and Basal Ganglia involvement in MRI of UE patients is a specific finding the absence of which does not rule out UE. Thus, simultaneous examination of clinical manifestation and laboratory test analyses, along with imaging findings, should also be taken into account.
本研究的目的是调查磁共振成像（MRI）对尿毒症性脑病的诊断结果，并描述MRI结果在尿毒症性脑病（UE）最终诊断中的作用。在这项前瞻性研究中，对总共20例入院的尿毒症性脑病患者进行了评估。分析了每位患者的临床表现、实验室和MRI影像学结果、人口统计学信息及临床结局。我们观察到，20例经前瞻性评估的UE患者未出现基底节受累或豆状核叉征（LFS）。然而，三分之二的患者有白质受累，80%的受试者有脑萎缩或皮质萎缩。动脉血气（ABG）分析显示，50%的患者患有代谢性酸中毒（n = 10）。本研究结果表明，尽管在UE患者的MRI中观察到豆状核叉征和基底节受累是一项特异性表现，但其缺如并不能排除UE。因此，还应同时考虑临床表现、实验室检查分析以及影像学结果。
