Bogolepova A N
Pirogov Russian National Research Medical University, Moscow, Russia.
Federal Center of Brain and Neurotechnologies, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(8):7-11. doi: 10.17116/jnevro20221220817.
In recent years, there has been an aging trend throughout the world. Globally, it is estimated that 50% of all older people have had at least one surgical operation. It is well known that compared with younger patients, people over 60 years of age have a higher risk of adverse postoperative outcomes. One of the possible complications of surgical intervention is the development of postoperative cognitive dysfunction (POCD), which is observed in about a quarter of patients. Among gerontological patients and those who underwent cardiac surgery, cognitive impairment is more common, reaching 80%. POCD has a negative impact on the course of recovery processes and life prognosis. There are a large number of risk factors for the development of POCD, associated both with the surgical intervention itself and with the patient's condition. One of the ways to prevent the occurrence of POCD is the use of neurometabolic drugs. Cytoflavin, containing inosine, nicotinamide, riboflavin and succinic acid, has demonstrated its effectiveness in relation to the risk of POCD in cardiac surgery patients. The results of a multicenter, double-blind, placebo-controlled, randomized study confirmed that Cytoflavin is an effective means of preventing and correcting postoperative cognitive disorders in high-risk patients.
近年来，全球出现了老龄化趋势。据估计，全球所有老年人中有50%至少接受过一次外科手术。众所周知，与年轻患者相比，60岁以上的人术后出现不良后果的风险更高。手术干预的可能并发症之一是术后认知功能障碍（POCD）的发生，约四分之一的患者会出现这种情况。在老年患者和接受心脏手术的患者中，认知障碍更为常见，发生率达80%。POCD对康复进程和生活预后有负面影响。POCD发生的风险因素众多，既与手术干预本身有关，也与患者状况有关。预防POCD发生的方法之一是使用神经代谢药物。含有肌苷、烟酰胺、核黄素和琥珀酸的细胞黄素已证明其对心脏手术患者发生POCD的风险有效。一项多中心、双盲、安慰剂对照、随机研究的结果证实，细胞黄素是预防和纠正高危患者术后认知障碍的有效手段。
