Chukanova E I, Chukanova A S, Rodionova D M
Pirogov Russian National Research Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(8):35-40. doi: 10.17116/jnevro202212208135.
Cerebrovascular diseases (CVDs) are one of the urgent problems of clinical neurology and the second most common cause of dementia. Vascular factors leading to the development of hypoxia, oxidative stress, mitochondrial, endothelial dysfunction and, ultimately, to the development of apoptosis with the formation of degenerative brain changes are considered among the main risk factors for the development of CVD. The most important mechanisms of the development of TFR are hypoxia and oxidative stress, which indicate the need for the use of drugs with antihypoxant and antioxidant activity. Such drugs include Mexidol (ethylmethylhydroxypyridine succinate). Mexidol directly affects the pathogenetic factors of the formation of ischemic-hypoxic brain damage, has a high clinical efficacy in the treatment of various forms of cerebral circulatory insufficiency.
脑血管疾病（CVDs）是临床神经病学的紧迫问题之一，也是痴呆症的第二大常见病因。导致缺氧、氧化应激、线粒体和内皮功能障碍发展，并最终导致细胞凋亡形成和脑退行性改变的血管因素，被认为是CVD发展的主要危险因素。TFR发展的最重要机制是缺氧和氧化应激，这表明需要使用具有抗缺氧和抗氧化活性的药物。这类药物包括美西多（琥珀酸乙甲基羟基吡啶）。美西多直接影响缺血缺氧性脑损伤形成的致病因素，在治疗各种形式的脑循环不全方面具有很高的临床疗效。
