Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Am J Physiol Cell Physiol. 2022 Oct 1;323(4):C1190-C1205. doi: 10.1152/ajpcell.00214.2022. Epub 2022 Aug 29.
N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic RNAs. This modification is regulated by three different factors (writers, erasers, and readers) and affects multiple aspects of RNA metabolism, including RNA splicing, nuclear export, translation, stability and decay. The m6A-mediated modification plays important roles in posttranscriptional regulation of gene expression and mediates a variety of cellular and biological processes. Accordingly, deregulation in m6A modification is closely related to the occurrence and development of human diseases. The liver is the largest digestive and metabolic organ in human and recent studies have shown that m6A modification is importantly implicated in liver cellular and physiological functions and in the pathogenesis of hepatic diseases and cancers. In the current review, we summarize the functions of m6A in RNA metabolism and its roles in liver cell biology and discuss its implication in hepatic diseases and carcinogenesis.
N6-甲基腺苷（m6A）是真核 RNA 中最普遍的内部修饰。这种修饰受三种不同的因素（writers、erasers 和 readers）调控，并影响 RNA 代谢的多个方面，包括 RNA 剪接、核输出、翻译、稳定性和降解。m6A 介导的修饰在基因表达的转录后调控中起着重要作用，并介导多种细胞和生物过程。因此，m6A 修饰的失调与人类疾病的发生和发展密切相关。肝脏是人体最大的消化和代谢器官，最近的研究表明，m6A 修饰在肝细胞的生理功能以及肝脏疾病和癌症的发病机制中起着重要作用。在本综述中，我们总结了 m6A 在 RNA 代谢中的功能及其在肝细胞核生物学中的作用，并讨论了其在肝脏疾病和癌症发生中的意义。
