Medical Oncology Department. Centro Hospitalar de Trás-os-Montes e Alto Douro. Vila Real. Portugal.
Urology Department. Centro Hospitalar Universitário São João. Porto. Portugal.
Acta Med Port. 2023 May 2;36(5):358-360. doi: 10.20344/amp.18350. Epub 2022 Aug 29.
Priapism may be a side effect of low-molecular-weight heparins, and its mechanism remains unknown. The authors present a clinical case of a 51-year-old male patient with oligodendroglioma. The patient presented ischemic priapism on the third month after starting tinzaparin, without other recent changes to his medication and he denied the use of other new medicines. The patient went through surgery and the erection was resolved but presented fibrosis of the cavernous body which left him with erectile dysfunction. Since this event, the patient is no longer receiving Heparin and has had no other episodes of priapism. The prompt recognition of this side effect may decrease its morbidity and consequent impact on the quality of life. More studies are needed to better understand its pathophysiology.
阴茎异常勃起可能是低分子肝素的一种副作用，其机制尚不清楚。作者报告了一例 51 岁男性患者患有少突胶质细胞瘤的临床病例。患者在开始使用替扎肝素的第三个月出现缺血性阴茎异常勃起，没有其他近期药物变化，也否认使用其他新药。患者接受了手术，勃起得到解决，但海绵体纤维化导致勃起功能障碍。自这一事件以来，该患者不再接受肝素治疗，也没有出现其他阴茎异常勃起的情况。及时识别这种副作用可能会降低其发病率，并对生活质量产生相应的影响。需要进一步研究以更好地了解其病理生理学。
