Külahçıoğlu Şeyhmus, Kültürsay Barkın, Çeneli Doğancan, Bıyıklı Kadir, Danışman Neşri, Karaçam Murat, Tuncer Şeref Berk, Demirci Koray, Eminoğlu Halit, Korun Okan, Karagöz Ali, Kaymaz Cihangir
Department of Cardiology, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
Metab Syndr Relat Disord. 2022 Oct;20(8):489-496. doi: 10.1089/met.2022.0046. Epub 2022 Aug 26.
Acute coronary syndrome (ACS) remains a major cause of morbidity and mortality worldwide. Although obesity is a risk factor for ACS, decreased mortality has been shown in overweight individuals. This study aims to determine the association of body fat parameters such as body fat percentage (BFP), relative fat mass (RFM), and coronary thrombus burden with angiographic thrombotic grade in a series of patients presenting with ACS. Three hundred ninety patients who underwent percutaneous coronary intervention were enrolled in the study. BFP was calculated using the U.S. Navy formula. RFM index was calculated using gender, height, and waist circumference regardless of weight. Body mass index (BMI) is calculated as the weight in kilograms divided by the square of body length in meters (kg/m). Two experienced interventional cardiologists reviewed coronary angiograms according to the TIMI thrombus scale. Patients were divided into groups according to thrombus classification and clinical status. RFM, which is an anthropometric measurement parameter for obesity, was inversely related to thrombus burden in patients with ACS. There were no significant differences between ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) groups according to demographic, clinical characteristics, and coronary risk factors. Likewise, RFM, BFP, and BMI were comparable between the two groups. BFP and RFM were lower in patients with thrombus present STEMI group compared with no thrombus group. Thrombus presence was also compared in the NSTEMI group, and BMI, BFP, and RFM were lower in patients with thrombus present NSTEMI group. Our analysis demonstrated that RFM was better than BFP and BMI for predicting thrombus presence in patients with ACS.
急性冠状动脉综合征（ACS）仍是全球发病和死亡的主要原因。尽管肥胖是ACS的一个危险因素，但超重个体的死亡率已显示有所下降。本研究旨在确定一系列ACS患者中体脂参数如体脂百分比（BFP）、相对脂肪量（RFM）和冠状动脉血栓负荷与血管造影血栓分级之间的关联。390例行经皮冠状动脉介入治疗的患者纳入本研究。BFP采用美国海军公式计算。RFM指数根据性别、身高和腰围计算，与体重无关。体重指数（BMI）计算为体重（千克）除以身高（米）的平方（kg/m²）。两位经验丰富的介入心脏病专家根据TIMI血栓量表对冠状动脉造影进行评估。患者根据血栓分类和临床状况分组。RFM作为肥胖的人体测量参数，与ACS患者的血栓负荷呈负相关。根据人口统计学、临床特征和冠状动脉危险因素，ST段抬高型心肌梗死（STEMI）组和非ST段抬高型心肌梗死（NSTEMI）组之间无显著差异。同样，两组之间的RFM、BFP和BMI具有可比性。STEMI组有血栓患者的BFP和RFM低于无血栓组。NSTEMI组也比较了血栓的存在情况，NSTEMI组有血栓患者的BMI、BFP和RFM较低。我们的分析表明，在预测ACS患者血栓存在方面，RFM优于BFP和BMI。
