Department of Anatomic Pathology, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Indonesia.
Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Indonesia.
Asian Pac J Cancer Prev. 2022 Aug 1;23(8):2749-2754. doi: 10.31557/APJCP.2022.23.8.2749.
This study aimed to investigate the association of sTILs with clinicopathological parameters and overall survival (OS) in patients with triple negative breast cancer (TNBC).
One hundred and twenty-five paraffin embedded tissue of patients with TNBC, collected from Dr. Sardjito General Hospital Yogyakarta, Indonesia, between 2008-2017, were used in this study. Stromal TILs were examined from hematoxylin and eosin (H&E)-stained samples, and classified as either low or high score using 20% cut-off. Analysis of the association of sTILs with clinicopathological parameters, relative risk (RR) and OS used 95% confidence interval (CI) with significance set as p<0.05.
The higher proportion of TNBC patients in this study were ≥40 years old (83.3%), high tumor grade (68%), tumor stage >IIIa (56%), alive (50.4%), and with low sTILs (54.4%). The results showed significant association between sTILs and a higher grade or a lower stage of tumor (B = 0.259, 95%CI = 0.090-0.468, p = 0.004 and B = -0.255, 95%CI = -0.433 - -0.080, p = 0.005, respectively ). Meanwhile sTILs were not associated with age at diagnosis (B = 0.027, 95%CI = -0.193 - 0.264 p = 0.758 nor 3-year OS of patients (HR = 0.342, 95%CI = 0.41 - 1.43 p = 0.402).
The results indicate that sTILs may serve as an additional pathological parameter for TNBC.
本研究旨在探讨间质肿瘤浸润淋巴细胞（sTILs）与三阴性乳腺癌（TNBC）患者临床病理参数和总生存期（OS）的关系。
本研究使用了 2008 年至 2017 年间从印度尼西亚日惹萨迪吉托综合医院收集的 125 例 TNBC 患者的石蜡包埋组织。使用苏木精和伊红（H&E）染色样本检测基质 TILs，并使用 20%的截断值将其分为低或高评分。使用 95%置信区间（CI）分析 sTILs 与临床病理参数、相对风险（RR）和 OS 的关系，显著性设置为 p<0.05。
本研究中，TNBC 患者≥40 岁的比例较高（83.3%），高肿瘤分级（68%）、肿瘤分期>IIIa（56%）、存活（50.4%）和低 sTILs（54.4%）的比例较高。结果表明，sTILs 与肿瘤分级较高或分期较低之间存在显著相关性（B = 0.259，95%CI = 0.090-0.468，p = 0.004 和 B = -0.255，95%CI = -0.433 - -0.080，p = 0.005）。同时，sTILs 与诊断时的年龄（B = 0.027，95%CI = -0.193 - 0.264，p = 0.758）或患者 3 年 OS 均无相关性（HR = 0.342，95%CI = 0.41-1.43，p = 0.402）。
结果表明，sTILs 可能成为 TNBC 的另一个病理参数。
