Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Asian Pac J Cancer Prev. 2022 Aug 1;23(8):2805-2811. doi: 10.31557/APJCP.2022.23.8.2805.
There is limited data available on the treatment outcomes of pediatric rhabdomyosarcoma (RMS) in Asian populations. Therefore, we aimed to review the baseline characteristics, clinical outcomes, and prognostic factors in children with RMS from Thailand.
The data of children under 15 years of age diagnosed with RMS between 2003 and 2019 from a large tertiary hospital in Southern Thailand were retrospectively reviewed. Descriptive statistics were utilized to describe the clinical characteristics. The Kaplan-Meier method was utilized to estimate survival. Cox proportional hazards regression analysis was utilized to determine prognostic factors that affect survival.
A total of 42 children RMS were included in this study. The median age at diagnosis was 6.4 years (IQR, 2.4-10.2). Among these patients, 11 (26%) were older than 10 years, and 13 (31%) presented with metastatic disease at diagnosis. The 5-year overall survival (OS) rate was 39% for all children. Age greater than 10 years (hazard ratio (HR): 3.3, 95% CI: 1.2-9.2) and metastatic disease at diagnosis (hazard ratio (HR): 2.8, 95% CI: 1.1-7.5) were independently associated with poorer survival. The 3-year OS for children with metastatic disease (stage IV) was 15% (95% CI: 4.3-55).
The percentage of metastatic disease in our cohort was higher than that in previous reports and may have contributed to a poorer outcome. Age greater than 10 years and metastatic disease at diagnosis were noted as adverse prognostic factors.
亚洲人群中关于儿童横纹肌肉瘤（RMS）治疗结果的数据有限。因此，我们旨在回顾泰国儿童 RMS 的基线特征、临床结果和预后因素。
回顾性分析 2003 年至 2019 年期间在泰国南部一家大型三级医院诊断为 RMS 的 15 岁以下儿童的数据。采用描述性统计描述临床特征。采用 Kaplan-Meier 法估计生存率。采用 Cox 比例风险回归分析确定影响生存的预后因素。
本研究共纳入 42 例 RMS 患儿。诊断时的中位年龄为 6.4 岁（IQR，2.4-10.2）。其中 11 例（26%）年龄大于 10 岁，13 例（31%）初诊时存在转移性疾病。所有儿童的 5 年总生存率（OS）为 39%。10 岁以上年龄（风险比（HR）：3.3，95%CI：1.2-9.2）和初诊时存在转移性疾病（HR：2.8，95%CI：1.1-7.5）与生存较差独立相关。有转移性疾病（IV 期）的儿童 3 年 OS 为 15%（95%CI：4.3-55）。
我们队列中转移性疾病的比例高于以往报道，可能导致预后较差。10 岁以上年龄和初诊时存在转移性疾病是不良预后因素。
