Xu Rongrong, Li Zhigang, Zhu Xiaojing, Guo Chen, Su Qiaoqiao, Peng Jianhao, Wang Zhanshan, Qian Yan, Li Xiaoqian, Xu Qiujin, Wei Yongjie
Center for Global Health, School of Public Health, Nanjing Medical University, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China.
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China.
Ecotoxicol Environ Saf. 2022 Sep 15;243:114013. doi: 10.1016/j.ecoenv.2022.114013. Epub 2022 Aug 26.
Both fine particulate matter (PM) and ozone (O) may have adverse effects on human health. However, previous studies on the effects of air pollutants mainly have focused on susceptible population, and evidence on healthy young adults is limited. We aimed to examine the associations of the two main air pollutants (PM and O) with lung function, inflammation and oxidative stress in healthy young adults. We recruited 30 healthy young adults for a longitudinal panel study in Beijing and implemented health examination seven times, including lung function (FEV and PEF) and biomarkers of inflammation and oxidative stress (i.e. C-reactive protein, CRP; interleukin-6, IL-6; malondialdehyde, MDA) from December 2019 to May 2021. Hourly ambient air pollutants data were obtained from the closest air quality monitoring station. Linear mixed-effect model was applied to explore the associations between air pollutants and lung function, inflammation and oxidative stress. We observed higher PM exposure was associated with decrement in lung function and increment in CRP and MDA. Each 10 μg/m increase in PM (lag 2 day) is associated with a 17.06 ml (95% CI: -31.53, -2.58) decrease in FEV, 46.34 ml/s (95% CI: -76.41, -16.27) decrease in PEF and increments of 2.86% (95% CI: 1.47%, 4.27%) in CRP, 1.63% (95% CI: 0.14%, 3.14%) in MDA respectively. However, there is no significant association between ozone exposure and health indicators. The study suggested that short-term exposure to PM may decrease lung function and induce inflammation and oxidative stress in healthy adults, but there is no association between O and each outcome.
细颗粒物（PM）和臭氧（O）都可能对人体健康产生不利影响。然而，以往关于空气污染物影响的研究主要集中在易感人群，而关于健康年轻成年人的证据有限。我们旨在研究两种主要空气污染物（PM和O）与健康年轻成年人肺功能、炎症和氧化应激之间的关联。我们招募了30名健康年轻成年人在北京进行纵向队列研究，并在2019年12月至2021年5月期间进行了七次健康检查，包括肺功能（FEV和PEF）以及炎症和氧化应激的生物标志物（即C反应蛋白，CRP；白细胞介素-6，IL-6；丙二醛，MDA）。每小时的环境空气污染物数据来自最近的空气质量监测站。采用线性混合效应模型来探讨空气污染物与肺功能、炎症和氧化应激之间的关联。我们观察到较高的PM暴露与肺功能下降以及CRP和MDA升高有关。PM每增加10 μg/m（滞后2天），FEV下降17.06 ml（95%CI：-31.53，-2.58），PEF下降46.34 ml/s（95%CI：-76.41，-16.27），CRP升高2.86%（95%CI：1.47%，4.27%），MDA升高1.63%（95%CI：0.14%，3.14%）。然而，臭氧暴露与健康指标之间没有显著关联。该研究表明，健康成年人短期暴露于PM可能会降低肺功能并引发炎症和氧化应激，但O与各项结果之间没有关联。
