Department of Surgery, University of Cambridge, Cambridge, UK.
Br J Surg. 2023 Jan 10;110(2):133-137. doi: 10.1093/bjs/znac293.
A major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an α-galactosidase enzyme from was used successfully to remove type B blood group antigens enzymatically from human kidneys using normothermic machine perfusion. This provides the first step for a strategy to overcome the ABO barrier in kidney transplantation.
移植的一个主要限制是供体和受者之间 ABO 血型相容性的要求。在这项研究中，使用来自 的 α-半乳糖苷酶，通过常温机器灌注成功地从人类肾脏中酶促去除 B 型血液组抗原。这为克服肾脏移植中 ABO 障碍的策略提供了第一步。
