Division of Medical Physics, Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany.
University of Applied Sciences Giessen, Institute of Medical Physics and Radiation Protection, Giessen, Germany; University Medical Center Göttingen, Department of Radiation Oncology, Göttingen, Germany.
Z Med Phys. 2023 Nov;33(4):463-478. doi: 10.1016/j.zemedi.2022.07.004. Epub 2022 Aug 26.
To employ the microDiamond and the microSilicon detector (mDD and mSD, both PTW-Freiburg, Germany) to determine the dose rate around a HDR Ir brachytherapy source (model mHDR-v2r, Elekta AB, Sweden).
The detectors were calibrated with a Co beam at the PTW Calibration Laboratory. Measurements around the Ir source were performed inside a PTW MP3 water phantom. The detectors were placed at selected points of measurement at radial distances r, ranging from 0.5 to 10 cm, keeping the polar angle θ = 90°. Additional measurements were performed with the mSD at fixed distances r = 1, 3 and 5 cm, with θ varying from 0 to 150°, 0 to 166°, and 0 to 168°, respectively. The corresponding mDD readings were already available from a previous work (Rossi et al., 2020). The beam quality correction factor of both detectors, as well as a phantom effect correction factor to account for the difference between the experimental geometry and that assumed in the TG-43 formalism, were determined using the Monte Carlo (MC) toolkit EGSnrc. The beam quality correction factor was factorized into energy dependence and volume-averaging correction factors. Using the abovementioned MC-based factors, the dose rate to water at the different points of measurement in TG-43 conditions was obtained from the measured readings, and was compared to the dose rate calculated according to the TG-43 formalism.
The beam quality correction factor was considerably closer to unity for the mDD than for the mSD. The energy dependence of the mDD showed a very weak radial dependence, similar to the previous findings showing a weak angular dependence as well (Rossi et al., 2020). Conversely, the energy dependence of the mSD decreased significantly with increasing distances, and also showed a considerably more pronounced angular dependence, especially for the smallest angles. The volume-averaging showed a similar radial dependence for both detectors: the correction had a maximal impact at 0.5 cm and then approached unity for larger distances, as expected. Concerning the angular dependence, the correction for the mSD was also similar to the one previously determined for the mDD (Rossi et al., 2020): a maximal impact was observed at θ = 0°, with values tending to unity for larger angles. In general, the volume-averaging was less pronounced for the mSD due to the smaller sensitive volume radius. After the application of the MC-based factors, differences between mDD dose rate measurements and TG-43 dose rate calculations ranged from -2.6% to +4.3%, with an absolute average difference of 1.0%. For the mSD, the differences ranged from -3.1% to +5.2%, with an absolute average difference of 1.0%. For both detectors, all differences but one were within the combined uncertainty (k = 2). The differences of the mSD from the mDD ranged from -3.9% to +2.6%, with the vast majority of them being within the combined uncertainty (k = 2). For θ ≠ 0°, the mDD was able to provide sufficiently accurate results even without the application of the MC-based beam quality correction factor, with differences to the TG-43 dose rate calculations from -1.9% to +3.4%, always within the combined uncertainty (k = 2).
The mDD and the mSD showed consistent results and appear to be well suitable for measuring the dose rate around HDR Ir brachytherapy sources. MC characterization of the detectors response is needed to determine the beam quality correction factor and to account for energy dependence and/or volume-averaging, especially for the mSD. Our findings support the employment of the mDD and mSD for source QA, TPS verification and TG-43 parameters determination.
使用 microDiamond 和 microSilicon 探测器(mDD 和 mSD,均为德国 PTW-Freiburg 制造)来测量 HDR Ir 近距离放射治疗源(Elekta AB 生产的 mHDR-v2r 型)周围的剂量率。
探测器在 PTW 校准实验室用 Co 束进行校准。在 PTW MP3 水模体内部进行 Ir 源周围的测量。探测器放置在径向距离 r(范围为 0.5 至 10 cm)的选定测量点上,保持极角 θ=90°。在固定距离 r=1、3 和 5 cm 处,用 mSD 进行附加测量,极角 θ 分别变化为 0 至 150°、0 至 166°和 0 至 168°。相应的 mDD 读数可从之前的工作(Rossi 等人,2020 年)中获得。使用蒙特卡罗(MC)工具包 EGSnrc 确定了两个探测器的束质校正因子,以及一个考虑实验几何形状与 TG-43 形式主义之间差异的体模效应校正因子。束质校正因子被分解为能量依赖性和体积平均校正因子。使用上述基于 MC 的因子,从测量读数中获得了在不同测量点的 TG-43 条件下水的剂量率,并将其与根据 TG-43 形式主义计算的剂量率进行了比较。
mDD 的束质校正因子比 mSD 更接近 1。mDD 的能量依赖性显示出非常弱的径向依赖性,与之前发现的弱角度依赖性相似(Rossi 等人,2020 年)。相反,mSD 的能量依赖性随距离的增加而显著下降,并且还显示出更明显的角度依赖性,特别是在最小角度。体积平均显示出两个探测器相似的径向依赖性:校正在 0.5 cm 处具有最大影响,然后对于较大距离接近 1,这是预期的。关于角度依赖性,mSD 的校正也类似于之前为 mDD 确定的校正(Rossi 等人,2020 年):在 θ=0°时观察到最大影响,随着角度的增大,值趋于 1。一般来说,由于较小的敏感体积半径,mSD 的体积平均效应不太明显。在应用基于 MC 的因子后,mDD 剂量率测量值与 TG-43 剂量率计算值之间的差异范围为-2.6%至+4.3%,平均绝对差异为 1.0%。对于 mSD,差异范围为-3.1%至+5.2%,平均绝对差异为 1.0%。对于两个探测器,除一个之外的所有差异都在组合不确定度(k=2)范围内。mSD 与 mDD 的差异范围为-3.9%至+2.6%,其中绝大多数都在组合不确定度(k=2)范围内。对于 θ≠0°,mDD 即使不应用基于 MC 的束质校正因子,也能够提供足够准确的结果,与 TG-43 剂量率计算值的差异范围为-1.9%至+3.4%,始终在组合不确定度(k=2)范围内。
mDD 和 mSD 显示出一致的结果,似乎非常适合测量 HDR Ir 近距离放射治疗源周围的剂量率。需要对探测器的响应进行 MC 特性描述,以确定束质校正因子,并考虑能量依赖性和/或体积平均,特别是对于 mSD。我们的发现支持使用 mDD 和 mSD 进行源 QA、TPS 验证和 TG-43 参数确定。