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新型高剂量率192铱近距离放射治疗源的Gafchromic胶片剂量测定法

Gafchromic film dosimetry of a new HDR 192Ir brachytherapy source.

作者信息

Ayoobian Navid, Asl Akbar Sarabi, Poorbaygi Hosein, Javanshir Mohammad Reza

机构信息

University of Isfahan.

出版信息

J Appl Clin Med Phys. 2016 Mar 8;17(2):194-205. doi: 10.1120/jacmp.v17i2.6005.

DOI:10.1120/jacmp.v17i2.6005
PMID:27074483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5874862/
Abstract

High-dose-rate (HDR) brachytherapy is a popular modality for treating cancers of the prostate, cervix, endometrium, breast, skin, bronchus, esophagus, and head and neck as well as soft-tissue sarcomas. Because of different source designs and licensing issues, there is a need for specific dosimetry dataset for each HDR source model. The main objective of the present work is to measure 2D relative dose distribution around a new prototype 192Ir source, referred to as IRAsource-HDR, in PMMA phantom in the framework of AAPM TG-43 and TG-55 recommendations for radial distances of 0.5cm to 4 cm. Radiochromic films (RCFs) Gafchromic EBT and HD-810 were used for measurements. The dose rate constant, Λ, of the source was determined to be 1.084± 4.6%, 1.129 ± 4.4%, and 1.112 ± 0.8% cGyh-1U-1 using EBT RCF, HD-810 RCF, and Monte Carlo (MC) simulation, respectively. The results obtained in this study are in good agreement with previously published data for HDR interstitial 192Ir-HDR sources with a maximum discrepancy of ± 4.5%. An acceptable agreement (within ± 2%) between MC calculations and RCFs measurements showed that HD-810 RCF dosimetry is as good as EBT RCF, within HDR brachytherapy, and justifies the use of specific data for this new source. These data could be used as a benchmark for dose calculations in the conventional brachytherapy treatment planning systems.

摘要

高剂量率(HDR)近距离放射治疗是治疗前列腺癌、宫颈癌、子宫内膜癌、乳腺癌、皮肤癌、支气管癌、食管癌、头颈癌以及软组织肉瘤的一种常用方式。由于源设计和许可问题的不同,每种HDR源模型都需要特定的剂量测定数据集。本研究的主要目的是在AAPM TG - 43和TG - 55建议的框架下,在PMMA体模中测量一种新的原型192Ir源(称为IRAsource - HDR)周围0.5厘米至4厘米径向距离的二维相对剂量分布。使用放射变色胶片(RCF)Gafchromic EBT和HD - 810进行测量。分别使用EBT RCF、HD - 810 RCF和蒙特卡罗(MC)模拟确定该源的剂量率常数Λ为1.084±4.6%、1.129±4.4%和1.112±0.8% cGyh-1U-1。本研究获得的结果与先前发表的关于HDR组织间192Ir - HDR源的数据高度一致,最大差异为±4.5%。MC计算与RCF测量之间可接受的一致性(在±2%以内)表明,在HDR近距离放射治疗中,HD - 810 RCF剂量测定与EBT RCF一样好,并证明了使用该新源的特定数据的合理性。这些数据可作为传统近距离放射治疗治疗计划系统中剂量计算的基准。

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