Departamento de Reumatología, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Departamento de Reumatología, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, México; Unidad de Investigación de Enfermedades Autoinmunes Sistémicas, Unidad Médica de Alta Especialidad, Hospital de Especialidades-Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, México.
Arch Med Res. 2022 Sep;53(6):610-616. doi: 10.1016/j.arcmed.2022.07.005. Epub 2022 Aug 26.
To investigate national temporal trends over time in mortality rates in patients with systemic sclerosis (SSc) in Mexico between 1998 and 2017.
Deaths between 1998 and 2017 were extracted from General Board of Health Information (DGIS) Open Access datasets. 2We identified all persons aged ≥15 years with a diagnosis of SSc (ICD-10 code M34). We calculated the age-standardized mortality rate (ASMR) for SSc and non-SSc (information provided by the National Institute of Statistics, Geography, and Informatics). A Joinpoint regression model was used to determine mortality trends by sex and geographic regions. Annual percentage change (APC) and average APC (AAPC) were calculated using Joinpoint analysis.
From 1998 to 2017, the overall ASMR of SSc increased (AAPC = 2.5%), whereas the ASMR for non-SSc remained stable. By subpopulations, females, and males with SSc had a significant uptrend in the ASMR (APC = 4.6 and 4.4%, respectively), between 1998 and 2008 for the former and between 1998 and 2010 for the later. Females had a non-significant ASMR uptrend between 2008 and 2017 and males a non-significant ASMR decline between 2010 and 2017. Women had a higher SSc-ASMR to non-SSc-ASMR ratio than males. The relative cumulative change between 1998 and 2017 differed between females (78.1%) and males (50.8%), and residents of the Southern region had the largest cumulative change (147.8%).
SSc mortality rate increased in Mexico between 1998 to 2017, with SSc mortality higher than non-SSc mortality. However, the SSc mortality rate steeply increased in the first ten years but has plateaued in the last 10 years of the study period. Variations by sex and geographic regions were also identified.
调查 1998 年至 2017 年期间墨西哥系统性硬化症（SSc）患者死亡率的国家时间趋势。
从公开访问的一般健康信息委员会（DGIS）数据集提取 1998 年至 2017 年的死亡人数。我们确定了所有年龄≥15 岁、患有 SSc（ICD-10 代码 M34）的患者。我们计算了 SSc 和非 SSc 的年龄标准化死亡率（ASMR）（由国家统计、地理和信息研究所提供的信息）。使用 Joinpoint 回归模型按性别和地理区域确定死亡率趋势。使用 Joinpoint 分析计算年百分比变化（APC）和平均 APC（AAPC）。
1998 年至 2017 年期间，SSc 的总体 ASMR 增加（AAPC=2.5%），而非 SSc 的 ASMR 保持稳定。按亚群划分，女性和男性 SSc 的 ASMR 呈显著上升趋势（APC 分别为 4.6%和 4.4%，前者始于 1998 年至 2008 年，后者始于 1998 年至 2010 年）。1998 年至 2017 年期间，女性 ASMR 呈非显著上升趋势，2010 年至 2017 年期间男性 ASMR 呈非显著下降趋势。女性 SSc-ASMR 与非 SSc-ASMR 之比高于男性。1998 年至 2017 年期间，女性的相对累积变化为 78.1%，男性为 50.8%，南部地区的居民累积变化最大（147.8%）。
1998 年至 2017 年期间，墨西哥 SSc 死亡率上升，SSc 死亡率高于非 SSc 死亡率。然而，SSc 死亡率在前十年急剧上升，但在研究期的最后十年趋于平稳。还确定了按性别和地理区域的变化。
