Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Department of Psychology, Tufts University, Boston, MA, USA.
Bone Marrow Transplant. 2022 Nov;57(11):1649-1656. doi: 10.1038/s41409-022-01792-6. Epub 2022 Aug 29.
Ovarian dysfunction is an important consequence of hematopoietic stem cell transplantation (HCT). Premature ovarian failure and infertility can severely impact the quality of life for the increasing number of female long-term survivors of HCT. Here, we review the impact of HCT on ovarian function, post-transplant fertility and birth outcomes, and the contemporaneous strategies to preserve fertility for these patients.
卵巢功能障碍是造血干细胞移植（HCT）的一个重要后果。HCT 后女性患者发生卵巢早衰和不孕会严重影响其生活质量，且此类长期生存的患者人数正在不断增加。在此，我们综述了 HCT 对卵巢功能、移植后生育力和妊娠结局的影响，以及当前针对这些患者保留生育力的策略。
