Vucetic Andrea, Ahmad Belal, Tang Terence
Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
Department of Radiation Oncology, London Regional Cancer Program, London Health Sciences Centre, London, ON N6A 5W9, Canada.
Oncol Lett. 2022 Aug 9;24(4):335. doi: 10.3892/ol.2022.13454. eCollection 2022 Oct.
Intracranial recurrence following initial cranial irradiation for extensive-stage small cell lung cancer (ES-SCLC) can often be a treatment dilemma given the aggressive nature of the disease, the overall poor prognosis and concerns regarding re-treatment toxicity. The present report describes the case of a 62-year-old man diagnosed with ES-SCLC and synchronous brain metastases who initially underwent whole brain radiotherapy, chemotherapy and consolidative thoracic radiotherapy. The patient was found to have a solitary intracranial recurrence at both 3.5 and 6 years after his diagnosis. On both occasions, the patient received salvage stereotactic radiation, 30 Gy in 5 fractions, and continues to remain functionally independent. Overall, the present case demonstrates that with the appropriate patient selection, aggressive local salvage of recurrent intracranial ES-SCLC with stereotactic radiation can yield excellent and durable clinical outcomes.
对于广泛期小细胞肺癌（ES-SCLC）患者，在初次颅脑放疗后发生颅内复发时，鉴于该疾病的侵袭性、总体预后较差以及对再治疗毒性的担忧，治疗方案往往难以抉择。本报告描述了一名62岁男性患者的病例，该患者被诊断为ES-SCLC并伴有同步脑转移，最初接受了全脑放疗、化疗以及巩固性胸部放疗。在诊断后的3.5年和6年时，该患者均出现了孤立性颅内复发。两次复发时，患者均接受了挽救性立体定向放射治疗，分5次给予30 Gy剂量，目前仍保持功能独立。总体而言，本病例表明，通过适当的患者选择，采用立体定向放射治疗对复发性颅内ES-SCLC进行积极的局部挽救治疗，可取得优异且持久的临床效果。
