Alqawasmeh Odai, Fok Ellis, Yim Howard, Li Tin, Chung Jacqueline, Chan David
Assisted Reproductive Technology, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Department of Biomedical Science, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China.
Hum Fertil (Camb). 2023 Jul;26(3):450-462. doi: 10.1080/14647273.2022.2098540. Epub 2022 Aug 30.
The human body harbours trillions of microbes, and their influence on human health has been explored in many parts of the human body, including the male reproductive system. From routine culturing to polymerise chain reaction (PCR) and high throughput DNA sequencing, several studies have identified bacteria in the male reproductive system. In this review, we discuss the past and current literature surrounding the testicular and semen microbiome in correlation with male infertility. We further highlight the potential benefits of probiotics as an alternative therapeutic option for male infertility. Although not conclusive, emerging data are indicating potential implications of certain bacterial members on male fertility. There is a general agreement on the negative impact of some pathogenic bacterial species on semen parameters, including sperm counts, motility, morphology, and DNA integrity. On the other hand, , known as a human-friendly bacteria, has shown protective effects on semen parameters, which makes it a potentially good probiotic. In order to confirm the findings of previous studies, more clinical studies with larger sample sizes and the right controls are needed.
人体中寄居着数万亿微生物，并且它们对人体健康的影响已在人体的许多部位得到研究，包括男性生殖系统。从常规培养到聚合酶链反应（PCR）和高通量DNA测序，多项研究已在男性生殖系统中鉴定出细菌。在本综述中，我们讨论了过去和当前围绕睾丸和精液微生物群与男性不育相关的文献。我们进一步强调了益生菌作为男性不育替代治疗选择的潜在益处。尽管尚无定论，但新出现的数据表明某些细菌成员对男性生育力有潜在影响。对于一些致病细菌种类对精液参数（包括精子数量、活力、形态和DNA完整性）的负面影响已达成普遍共识。另一方面， 作为一种对人体有益的细菌，已显示出对精液参数的保护作用，这使其成为一种潜在的优质益生菌。为了证实先前研究的结果，需要更多样本量更大且有适当对照的临床研究。
