γ-Secretase as a drug target for familial Alzheimer's disease: the road less traveled.
作者信息
Wolfe Michael S
机构信息
Department of Medicinal Chemistry, University of Kansas, 1567 Irving Hill Road, GLH-2115, Lawrence, KS 66045, USA.
出版信息
Future Med Chem. 2022 Oct;14(19):1341-1343. doi: 10.4155/fmc-2022-0178. Epub 2022 Aug 30.
Abstract
摘要
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One Size Does Not Fit All: The Past, Present and Future of Cystic Fibrosis Causal Therapies.一概而论：囊性纤维化因果治疗的过去、现在和未来。
Cells. 2022 Jun 8;11(12):1868. doi: 10.3390/cells11121868.
2
Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues.淀粉样蛋白前体中的家族性阿尔茨海默病突变通过 γ-分泌酶改变蛋白水解，从而增加≥45 个残基的淀粉样 β 肽。
J Biol Chem. 2021 Jan-Jun;296:100281. doi: 10.1016/j.jbc.2021.100281. Epub 2021 Jan 12.
3
The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation.淀粉样蛋白级联反应与阿尔茨海默病治疗学：理论与观察。
Lab Invest. 2019 Jul;99(7):958-970. doi: 10.1038/s41374-019-0231-z. Epub 2019 Feb 13.
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Recognition of the amyloid precursor protein by human γ-secretase.人γ-分泌酶对淀粉样前体蛋白的识别。
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Dysfunctional γ-Secretase in Familial Alzheimer's Disease.家族性阿尔茨海默病中功能失调的γ-分泌酶
Neurochem Res. 2019 Jan;44(1):5-11. doi: 10.1007/s11064-018-2511-1. Epub 2018 Apr 4.
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Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.早老素-1中138个致病突变对γ-分泌酶体外产生Aβ42和Aβ40肽的影响分析。
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E476-E485. doi: 10.1073/pnas.1618657114. Epub 2016 Dec 5.
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Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon?γ-分泌酶调节剂：即将问世的新型阿尔茨海默病药物？
J Med Chem. 2016 Aug 25;59(16):7389-409. doi: 10.1021/acs.jmedchem.5b01960. Epub 2016 Apr 5.
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JAMA Neurol. 2015 Nov;72(11):1324-33. doi: 10.1001/jamaneurol.2015.0607.
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Lancet Respir Med. 2013 Apr;1(2):158-63. doi: 10.1016/S2213-2600(12)70057-7. Epub 2013 Jan 30.
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