Ismaeel Nadia, Zhuo Zhixing, Imran Sajid, Yuan Dan, Yao Yingming
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University, Suzhou 215123, People's Republic of China.
Dalton Trans. 2022 Sep 20;51(36):13892-13901. doi: 10.1039/d2dt02642b.
Rare earth/lithium complexes stabilized by ethylenediamine-bridged bis(phenolate) ligands have been synthesized and characterized. In addition to five rare earth/lithium amides isolated as major complexes, two other rare earth/lithium complexes bearing two phenolate ligands were also isolated. The activities of rare earth/lithium amides in catalyzing the amidation of aldehydes and amines were studied, which revealed that the yttrium/lithium complex was highly active for a wide range of substrates, generating 58 examples of amides in 42-99% yields under mild conditions (, room temperature, 3-hour reaction time, additive-free). More importantly, this is the first example of rare earth-based catalysts capable of catalyzing the amidation of primary aliphatic amines.
通过乙二胺桥联双（酚盐）配体稳定的稀土/锂配合物已被合成并表征。除了分离出五种作为主要配合物的稀土/锂酰胺外，还分离出另外两种带有两个酚盐配体的稀土/锂配合物。研究了稀土/锂酰胺在催化醛和胺的酰胺化反应中的活性，结果表明钇/锂配合物对多种底物具有高活性，在温和条件下（室温，反应时间3小时，无添加剂）以42 - 99%的产率生成了58个酰胺实例。更重要的是，这是能够催化伯脂肪胺酰胺化反应的稀土基催化剂的首个实例。
