Beyond the fluorescence labelling of novel nitrogen-doped silicon quantum dots: the reducing agent and stabilizer for preparing hybrid nanoparticles and antibacterial applications.

Silicon quantum dots (SiQDs) have fully demonstrated their applicability in light of their fluorescence. The extension of their applications to other fields, especially considering their excellent biocompatibility, would be more appealing. Herein, a kind of versatile nitrogen-doped silicon quantum dot (N-SiQD) was facilely synthesized a one-pot hydrothermal method with 3-aminopropyltrimethoxysilane and tetraethylpentylamine as sources. The N-SiQDs were used as a probe for bacterial imaging owing to their good fluorescence properties, stability and biocompatibility. Besides, owing to N doping rendering the N-SiQDs stronger reducibility and Au affinity, the N-SiQDs displayed unique reduction capability, and were attempted as a reducing agent and stabilizer for the synthesis of the nanocomposite, N-SiQDs stabilized Au nanoparticles (N-SiQDs-AuNPs), under mild conditions. The N-SiQDs-AuNPs showed superior catalytic performance to citric-AuNPs due to the synergistical catalytic effect. In addition, the N-SiQDs exhibited good antibacterial properties against Gram-positive () and Gram-negative bacteria () without obvious negative influence on the cells, particularly avoiding the use of any other external stimulation. This study may open a new avenue to use SiQDs for the synthesis of nanocomposites and other biomedicine applications beyond as a fluorescent probe.