Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin, 150081, China.
Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, 723 West Michigan Street, SL220, Indianapolis, IN, 46202, USA.
J Bone Miner Metab. 2023 May;41(3):365-370. doi: 10.1007/s00774-022-01363-1. Epub 2022 Aug 30.
Wnt signaling plays a critical role in loading-driven bone formation and bone homeostasis, whereas its activation in cancer cells promotes their progression. Currently, major research efforts in cancer treatment have been directed to the development of Wnt inhibitors. Recent studies on tumor-bone interactions, however, presented multiple lines of evidence that support a tumor-suppressive role of Lrp5, a Wnt co-receptor, and β-catenin, in Wnt signaling. This review describes the action of Wnt signaling as a double-edged sword in the bone microenvironment and suggests the possibility of a novel option for protecting bone from cancer.
Wnt 信号通路在加载驱动的骨形成和骨内稳态中起着关键作用，而其在癌细胞中的激活则促进了癌细胞的进展。目前，癌症治疗的主要研究方向是开发 Wnt 抑制剂。然而，最近关于肿瘤-骨相互作用的研究提供了多方面的证据，支持 Wnt 共受体 Lrp5 和 Wnt 信号通路中的β-连环蛋白在肿瘤中的抑制作用。本综述描述了 Wnt 信号通路在骨微环境中作为双刃剑的作用，并提出了一种保护骨骼免受癌症侵害的新选择的可能性。
