Abouelatta Mahmoud M, Shalaby Osama E, Awara Amr M, Kikkawa Don O, Eldesouky Mohammed A
Division of Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology, Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Division of Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology, Shiley Eye Institute, University of California, La Jolla, San Diego, CA, USA.
Int Ophthalmol. 2023 Mar;43(3):725-731. doi: 10.1007/s10792-022-02471-7. Epub 2022 Aug 30.
evaluation of the role of combined injection of triamcinolone acetonide with 5 Fluorouracil in treatment of the enlarged extraocular muscles secondary to chronic non-specific non-infectious inflammation.
injection of 0.1 ml of triamcinolone acetonide 40 mg/ml and 0.1 ml of 5 Fluorouracil 50 mg/ml in the enlarged extraocular muscles secondary to chronic non-specific non-infectious inflammation in 6 patients, after the confirmation of the histopathological diagnosis of these patients by revising their medical records.
There was a significant improvement in the visual acuity, in addition to a significant improvement also in the clinical and the radiological features in the patients who were consented for the trial of the new injection protocol. However, there was failure of clinical and radiological improvement in one case presented with sever fibrosis. There was a significant absence of the side effects in all patients except for one patient that reported discomfort near the inner canthus.
The new protocol of the treatment is a promising modality that can be used in the chronic non-infectious inflammation without extensive fibrosis.
评估曲安奈德与5-氟尿嘧啶联合注射在治疗慢性非特异性非感染性炎症继发的眼外肌增粗中的作用。
在6例慢性非特异性非感染性炎症继发眼外肌增粗的患者中，经查阅病历确认其组织病理学诊断后，在增粗的眼外肌中注射0.1 ml 40 mg/ml的曲安奈德和0.1 ml 50 mg/ml的5-氟尿嘧啶。
同意接受新注射方案试验的患者，其视力有显著改善，临床和影像学特征也有显著改善。然而，1例出现严重纤维化的患者临床和影像学改善失败。除1例患者报告内眦附近不适外，所有患者均未出现明显副作用。
新的治疗方案是一种有前景的治疗方式，可用于无广泛纤维化的慢性非感染性炎症。
