基于支架的冠状动脉疾病基因递送
Stent-Based Gene Delivery for Coronary Disease.
机构信息
The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
出版信息
Methods Mol Biol. 2022;2573:217-233. doi: 10.1007/978-1-0716-2707-5_17.
Abstract
Percutaneous coronary interventions (PCI) are the mainstay for treatment of advanced coronary disease. A majority of PCI involve deployment of a stent in the affected vascular segment. This chapter introduces the concept of using stents as a platform for delivering gene therapies to the vasculature with the overarching aim of mitigating in-stent restenosis (ISR), late stent thrombosis (LST), and neoatherosclerosis (NA), a triad of delayed complications that reduce the overall success rate of PCI. The chapter provides a detailed methodology for coatless reversible attachment of adenoviral (Ad) and adeno-associated viral (AAV) vectors to the metal stent struts along with representative in vitro and in vivo results.
摘要
经皮冠状动脉介入治疗（PCI）是治疗晚期冠状动脉疾病的主要手段。大多数 PCI 都涉及在受影响的血管节段中部署支架。本章介绍了使用支架作为平台将基因疗法递送到血管系统的概念，其总体目标是减轻支架内再狭窄（ISR）、晚期支架血栓形成（LST）和新动脉粥样硬化（NA），这三联征的延迟并发症降低了 PCI 的整体成功率。本章提供了一种详细的方法，用于将腺病毒（Ad）和腺相关病毒（AAV）载体无涂层可逆地附着到金属支架支柱上，并提供了代表性的体外和体内结果。
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