[Effect of complications on the rate of gastric secretion and acidity in duodenal ulcer].

The effect of the complications of duodenal ulcer on the rate of gastric secretion and acidity was studied under the conditions of maximum stimulation with pentagastrin. A total of 440 patients were studied. It has been established that the volume of gastric secretion and acid secretion are significantly higher in complications than in the absence of complications. The elevated values of gastric secretion and acid production in the patients with complicated duodenal ulcer are determined by their predominant elevation in case of past perforations and in case of stenosis of pylorus in particular. As compared with the patients without complications, the patients with the two indicated complications have 1.11 to 1.42 and 1.15 to 1.92 times higher indices respectively. The elevation of the parameters in past histories of gastrointestinal hemorrhages is rather small. The chronic reactive hepatitis, originating as a complication of duodenal ulcer, has lower values of gastric secretion and acidity as compared with the non-complicated form of the disease. The mean values, however, of none of the indices drop under the norm but range within the upper physiological limits.