Zbaida S, Kariv R, Fischer P, Gilhar D
Xenobiotica. 1987 May;17(5):617-21. doi: 10.3109/00498258709043968.
Theophylline and caffeine undergo N-demethylation and hydroxylation by Fenton's reagent to give uric acid derivatives; theophylline is oxidized mainly to 1-methyluric acid, and 1,3-dimethyluric acid and 1-methyluric acid are the major products obtained from caffeine. Theobromine undergoes predominantly N-demethylation to give 7-methylxanthine. The nature of the products indicate that these reactions simulate hepatic drug metabolism.
茶碱和咖啡因通过芬顿试剂进行N-去甲基化和羟基化反应生成尿酸衍生物；茶碱主要被氧化为1-甲基尿酸，而咖啡因的主要产物是1,3-二甲基尿酸和1-甲基尿酸。可可碱主要进行N-去甲基化反应生成7-甲基黄嘌呤。产物的性质表明这些反应模拟了肝脏药物代谢。
