扫描离子电导显微镜揭示水溶性富勒烯对巨噬细胞表面超微结构的影响。
Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy.
作者信息
Ruan Hefei, Zhang Xuejie, Yuan Jinghe, Fang Xiaohong
机构信息
Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences Beijing China
Tsinghua-Peking University Joint Center for Life Sciences, School of Medicine, Tsinghua University Beijing China.
出版信息
RSC Adv. 2022 Aug 10;12(34):22197-22201. doi: 10.1039/d2ra02403a. eCollection 2022 Aug 4.
C-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples.
C-富勒烯在抗病毒、药物递送、光动力疗法及其他生物医学应用方面具有独特潜力。然而，关于它们对巨噬细胞表面形态和超微结构的影响却知之甚少。在此，我们通过使用非接触式扫描离子电导显微镜（SICM），研究了两种水溶性富勒烯对巨噬细胞表面超微结构和功能的影响。结果表明，这些富勒烯有望成为一种吞噬作用抑制剂，且SICM将是研究黏附性和易碎样品形态信息的极佳工具。
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