Ningxia Medical University, Ningxia 750004, China.
Department of Otolaryngology Head and Neck Surgery, Second Affiliated Hospital of Ningxia Medical University Yinchuan First People's Hospital, Ningxia 750004, China.
Contrast Media Mol Imaging. 2022 Aug 8;2022:8990629. doi: 10.1155/2022/8990629. eCollection 2022.
Allergic rhinitis is one of the common chronic inflammatory diseases of the nasal mucosa. In order to investigate the effect of zinc on ovalbumin induced allergic rhinitis in BALB/C male mice based on NF-KB signaling pathway, thirty BALB/C male mice are randomly divided into three groups: control group, ovalbumin induced allergic rhinitis asthma group and zinc intervention group. The experimental results show that Zinc supplementation in allergic asthma mice with allergic rhinitis correct the immune response of TH2 cells by inhibiting THE NF-KB signaling pathway, reduce the infiltration of inflammatory cells into lung nasal tissue, and reduce airway co-hyperreactivity to improve the clinical symptoms of asthma and play an immune protective role.
变应性鼻炎是鼻黏膜的一种常见慢性炎症性疾病。本研究旨在基于 NF-κB 信号通路探讨锌对卵清蛋白诱导的 BALB/C 雄性小鼠变应性鼻炎的影响，将 30 只雄性 BALB/C 小鼠随机分为三组：对照组、卵清蛋白诱导的变应性鼻炎哮喘组和锌干预组。实验结果表明，锌通过抑制 TH2 细胞的 NF-κB 信号通路，纠正变应性鼻炎哮喘小鼠的免疫反应，减少炎性细胞浸润到肺和鼻组织，降低气道对高反应性，改善哮喘的临床症状，发挥免疫保护作用。
