（+）-苦皮藤素的全合成：一个跨环 [2+2] 环加成/断裂方法。
Total Synthesis of (+)-Mutilin: A Transannular [2+2] Cycloaddition/Fragmentation Approach.
机构信息
Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education and Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
出版信息
J Am Chem Soc. 2022 Aug 31;144(34):15462-15467. doi: 10.1021/jacs.2c06934. Epub 2022 Aug 22.
A new and enantioselective total synthesis of the diterpenoid (+)-mutilin is described. Following a Claisen rearrangement approach to construct the 6,9-bicycle, a transannular [2+2] photocycloaddition and the ensuing ring-opening reaction were implemented to forge the characteristic 5-6-8 propellane-like skeleton. Subsequent late-stage alkylations and reduction completed the synthesis.
描述了一种新型的、对映选择性的二萜（+）-mutilin 全合成方法。在采用 Claisen 重排方法构建 6,9-双环之后，进行了反式环加成和随后的开环反应，形成了特征性的 5-6-8 类轮烷骨架。随后的晚期烷基化和还原完成了合成。
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