Lazarus P
Z Gesamte Inn Med. 1987 Apr 1;42(7):187-90.
Underlying literature and taking into consideration own experiences in the anticholinergic syndrome the following view is taken: Physostigmine salicylate is the remedy of choice for the treatment of the anticholinergic syndrome and altogether causes only slight side effects. While for differential-diagnostic reasons the application is recommended under hospital conditions, the pre-hospital application is to be estimated as problematical. The improvement of the clinical symptoms under the influence of physostigmine salicylate must not lead to the neglect of the control of the patient. A differentiated use of physostigmine salicylate is necessary, and it cannot be regarded as "universal antidote" in intoxications caused by central-nervous effective substances.
根据相关文献并结合自身在抗胆碱能综合征方面的经验,形成以下观点:水杨酸毒扁豆碱是治疗抗胆碱能综合征的首选药物,且总体副作用轻微。虽然出于鉴别诊断的原因,建议在医院条件下使用,但院前使用被认为存在问题。水杨酸毒扁豆碱作用下临床症状的改善绝不能导致对患者监测的忽视。有必要区别使用水杨酸毒扁豆碱,且它不能被视为中枢神经活性物质中毒的“通用解毒剂”。