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放疗后晚期并发声门上狭窄:1 例报告。

Supraglottic stenosis as a late complication of radiotherapy: a case report.

机构信息

Universidade Federal de Goiás, Goiânia, GO, Brazil.

出版信息

Einstein (Sao Paulo). 2022 Aug 29;20:eRC0035. doi: 10.31744/einstein_journal/2022RC0035. eCollection 2022.

DOI:10.31744/einstein_journal/2022RC0035
PMID:36043601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9417347/
Abstract

Nasopharyngeal carcinoma is rare and affect mainly men between the fourth and sixth decades of life. The clinic is characterized to be nonspecific and the main complaints or findings related to this disease are: cervical mass, aural dysfunction, and headache. The basis of treatment is radiotherapy that involves a wide field of irradiation of normal tissues, which usually generates sequelae with direct implications for quality of life. We report a case of a nasopharyngeal carcinoma treated with radiotherapy and chemotherapy that evolved, after 8 years, into supraglottic stenosis. We emphasize the relevance of clinical follow-up after radiotherapy, particularly due to the late sequelae and the relevance of using radiotherapy devices with a more focal cancer field, in order to minimize complications.

摘要

鼻咽癌罕见,主要影响 40 至 60 岁的男性。其临床特征是非特异性的,与该疾病相关的主要症状或发现包括:颈部肿块、听觉功能障碍和头痛。治疗的基础是放疗,它涉及广泛的正常组织照射,这通常会产生对生活质量有直接影响的后遗症。我们报告了一例鼻咽癌患者,经放疗和化疗治疗,8 年后发展为声门上狭窄。我们强调放疗后临床随访的重要性,特别是由于迟发性后遗症以及使用更聚焦于癌症部位的放疗设备的相关性,以最小化并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f33/9417347/c0f7c589f108/2317-6385-eins-20-eRC0035-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f33/9417347/b5e5d6946a9a/2317-6385-eins-20-eRC0035-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f33/9417347/c0f7c589f108/2317-6385-eins-20-eRC0035-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f33/9417347/b5e5d6946a9a/2317-6385-eins-20-eRC0035-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f33/9417347/c0f7c589f108/2317-6385-eins-20-eRC0035-gf02.jpg

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本文引用的文献

1
Surgical Management of Supraglottic Stenosis Using Intubationless Optiflow.使用无插管Optiflow技术治疗声门上狭窄的手术管理
Ann Otol Rhinol Laryngol. 2017 Sep;126(9):669-672. doi: 10.1177/0003489417720220. Epub 2017 Aug 2.
2
Nasopharyngeal carcinoma: a review.鼻咽癌:综述
Semin Diagn Pathol. 2015 Jan;32(1):54-73. doi: 10.1053/j.semdp.2015.02.021. Epub 2015 Feb 25.
3
Evidence on effectiveness of intensity-modulated radiotherapy versus 2-dimensional radiotherapy in the treatment of nasopharyngeal carcinoma: Meta-analysis and a systematic review of the literature.
调强放射治疗与二维放射治疗在鼻咽癌治疗中的有效性证据:Meta分析及文献系统综述
Head Neck. 2016 Apr;38 Suppl 1:E2130-42. doi: 10.1002/hed.23977. Epub 2015 Jun 17.
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Late toxicities after intensity-modulated radiotherapy for nasopharyngeal carcinoma: patient and treatment-related risk factors.调强放疗治疗鼻咽癌后的晚期毒性:患者和治疗相关的危险因素。
Br J Cancer. 2014 Jan 7;110(1):49-54. doi: 10.1038/bjc.2013.720. Epub 2013 Nov 19.
5
Supraglottic stenosis: etiology and treatment of a rare condition.声门上狭窄:一种罕见病症的病因及治疗
Ann Otol Rhinol Laryngol. 2013 Mar;122(3):205-9. doi: 10.1177/000348941312200310.
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Post-treatment late complications of nasopharyngeal carcinoma.鼻咽癌治疗后的晚期并发症。
Eur Arch Otorhinolaryngol. 2012 Nov;269(11):2401-9. doi: 10.1007/s00405-011-1922-2. Epub 2012 Jan 15.