Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151401, India.
Curr Pharm Des. 2022;28(32):2664-2676. doi: 10.2174/1381612828666220829120630.
Heat shock protein 90 (Hsp90) is a chaperone protein that prevents many other proteins from aggregating by folding them in a certain way. Hsp90 consists of three structural domains: N-terminal, middle and C-terminal domains. Hsp90 has many activities in numerous proteins and signaling pathways like chimeric fusion proteins, steroid hormone receptors, tumor suppressor genes, and cell cycle regulatory proteins. The role of Hsp90 is not only in cancer but also in other diseases like COVID-19, leishmaniasis, diabetes, flavi virus, systemic sclerosis, grass carp reovirus, psoriasis, malaria, cardiac fibrosis, and alcohol-related liver diseases. This review is a compilation of the pharmacological profile of Hsp90 inhibitors, problems associated with them, and suggested remedies for the same.
热休克蛋白 90（Hsp90）是一种伴侣蛋白，它通过以特定方式折叠蛋白质来防止许多其他蛋白质聚集。Hsp90 由三个结构域组成：N 端、中间和 C 端结构域。Hsp90 在许多蛋白质和信号通路中具有多种活性，如嵌合融合蛋白、甾体激素受体、肿瘤抑制基因和细胞周期调节蛋白。Hsp90 的作用不仅在于癌症，还在于其他疾病，如 COVID-19、利什曼病、糖尿病、黄病毒、系统性硬化症、草鱼虹彩病毒、银屑病、疟疾、心脏纤维化和酒精相关肝病。这篇综述是对 Hsp90 抑制剂的药理学特征、与之相关的问题以及对这些问题的建议补救措施的汇编。
