Faculty of Physical Therapy and Rehabilitation, Department of Cardiorespiratory Physiotherapy and Rehabilitation, Sihhiye Campus, Hacettepe University, Samanpazari, Ankara, Turkey.
Faculty of Medicine, Department of Pediatric Chest Medicine, Sihhiye Campus, Hacettepe University, Ankara, Turkey.
Physiother Theory Pract. 2024 Feb;40(2):230-240. doi: 10.1080/09593985.2022.2116300. Epub 2022 Aug 31.
Abnormal glucose tolerance (AGT) in cystic fibrosis (CF) affects lung function and clinical parameters, including aerobic fitness. However, its effects on physical activity level (PAL), anaerobic power (AP), and muscle strength (MS) in children and adolescents are unknown.
To investigate aerobic fitness, PAL, AP, and MS in pediatric patients with mild-to-moderate CF and AGT.
The study included children and adolescents with CF aged 10-18 years. Participants underwent a pulmonary function test, quadriceps, and handgrip MS measurement, vertical jump test to assess AP, and six-minute walk test (6MWT) to assess aerobic fitness. Bouchard's Three-Day Physical Activity record was used to determine PAL.
Height z-score (p = .006), 6MWT (p = .024), handgrip (p = .028), quadriceps MS (p = .044), and AP (p = .036) were significantly lower in AGT (n = 21) than normal glucose tolerance (NGT) (n = 19). In the AGT group, glycosylated hemoglobin (HbA1c) was significantly associated with forced expiratory volume in one second (FEV) (p = .046). 6MWT distance (6MWD) was associated with height (p = .008), FEV (p = .001), forced vital capacity (FVC) (p = .001), forced expiratory flow from 25% to 75% (FEF) (p = .030), handgrip MS (p = .012), and PAL (p = .034). After adjusting for height and FEV, the groups had similar 6MWD, MS, and AP (p > .05); also, insulin was associated with MS and AP but not with 6MWT or quadriceps MS.
Measures of aerobic fitness, MS, and AP are lower in AGT, but after adjusting for height and FEV, aerobic fitness, MS, and AP do not show substantial differences. Insulin sensitivity and resistance are associated with MS and AP.
囊性纤维化（CF）患者的葡萄糖耐量异常（AGT）会影响肺功能和临床参数，包括有氧健身。然而，其对儿童和青少年的身体活动水平（PAL）、无氧能力（AP）和肌肉力量（MS）的影响尚不清楚。
研究轻中度 CF 伴 AGT 患儿的有氧健身、PAL、AP 和 MS。
该研究纳入了 10-18 岁的 CF 患儿和青少年。参与者接受了肺功能测试、股四头肌和手握力 MS 测量、垂直跳跃测试以评估 AP 以及 6 分钟步行测试（6MWT）以评估有氧健身。Bouchard 的三天体力活动记录用于确定 PAL。
AGT 组（n=21）身高 z 评分（p=0.006）、6MWT（p=0.024）、手握力（p=0.028）、股四头肌 MS（p=0.044）和 AP（p=0.036）均显著低于正常葡萄糖耐量（NGT）组（n=19）。在 AGT 组中，糖化血红蛋白（HbA1c）与用力呼气量（FEV）显著相关（p=0.046）。6MWT 距离（6MWD）与身高（p=0.008）、FEV（p=0.001）、用力肺活量（FVC）（p=0.001）、25%至 75%用力呼气流量（FEF）（p=0.030）、手握力 MS（p=0.012）和 PAL（p=0.034）相关。在调整身高和 FEV 后，两组的 6MWD、MS 和 AP 无显著差异（p>0.05）；胰岛素与 MS 和 AP 相关，但与 6MWT 或股四头肌 MS 无关。
AGT 患儿的有氧健身、MS 和 AP 较低，但在调整身高和 FEV 后，有氧健身、MS 和 AP 无显著差异。胰岛素敏感性和抵抗与 MS 和 AP 相关。
