Obstetrics and Gynecology Unit, DIM Department, University of Bari, Italy.
Obstetrics and Gynecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari, Italy .
Acta Biomed. 2022 Aug 31;93(4):e2022051. doi: 10.23750/abm.v93i4.11695.
BRCA1/2 are tumour-suppressor genes involved in DNA homologous recombination and ovarian cancer development. The study evaluated the risk of tumor cancer in women presenting the BRCA mutations.
Risk-reducing surgery (RRS) was performed in 100 patients carrying BRCA1 (aged between 30-73 years, median age was 51 years) and BRCA 2 mutation (aged between 36-70 years, median age was 53 years). Fifty-eight patients had previous history of breast cancer.
Between the 100 patients, 82 women underwent risk-reducing salpingo-oophorectomy (RRSO) through a laparoscopic minimally invasive approach, 7 (7 %) underwent laparoscopic RRSO and contextual hysterectomy, 1 woman (1 %) underwent RRSO through a laparotomic approach and 10 women (10 %) laparotomic RRSO and hysterectomy. During 5 (5 %) laparoscopic RRSO, prophylactic bilateral mastectomy was also performed. Early and late complication occurred in 3 patients (3 %). Two patients (2 %) were found to have occult Serous Tubal Intraepithelial Carcinoma (STIC) and three patients (3 %) occult cancer.
RRSO is safe and feasible in BRCA mutation carriers. The procedure is effective for genetic prevention of ovarian cancer.
BRCA1/2 是参与 DNA 同源重组和卵巢癌发展的肿瘤抑制基因。本研究评估了携带 BRCA 突变的女性患肿瘤癌症的风险。
对 100 名携带 BRCA1（年龄 30-73 岁，中位年龄 51 岁）和 BRCA2 突变（年龄 36-70 岁，中位年龄 53 岁）的患者进行了降低风险的手术（RRS）。58 例患者有乳腺癌病史。
在 100 名患者中，82 名女性通过腹腔镜微创途径进行了风险降低的输卵管卵巢切除术（RRSO），7 名（7%）女性通过腹腔镜 RRSO 和子宫切除术，1 名女性（1%）通过剖腹手术进行 RRSO，10 名女性（10%）进行剖腹 RRSO 和子宫切除术。在 5 例（5%）腹腔镜 RRSO 中，还预防性地进行了双侧乳房切除术。3 名患者（3%）出现早期和晚期并发症。2 名患者（2%）发现有隐匿性输卵管上皮内癌（STIC），3 名患者（3%）发现隐匿性癌症。
RRSO 在 BRCA 突变携带者中是安全且可行的。该手术对于卵巢癌的遗传预防是有效的。
