Noblitt Bryce, Higgins John, Kopytek Katherine, Brehm Christoph, Gupta Nikita
Department of Otolaryngology-Head and Neck Surgery, University of Kentucky.
Department of Mechanical Engineering, University of Kentucky.
J Craniofac Surg. 2023;34(1):337-342. doi: 10.1097/SCS.0000000000008961. Epub 2022 Aug 30.
The objective analysis of nasal airflow stands to benefit greatly from the adoption of computational fluid dynamic (CFD) methodologies. In this emerging field, no standards currently exist in regard to the ideal modeling parameters of the nasal airway. Such standards will be necessary for this tool to become clinically relevant.
Human nasal airways were modeled from a healthy control, segmented, and analyzed with an in-house immersed boundary method. The segmentation Hounsfield unit (HU) threshold was varied to measure its effect in relation to airflow velocity magnitude and pressure change.
Surface area and volume have a linear relationship to HU threshold, whereas CFD variables had a more complex relationship.
The HU threshold should be included in nasal airflow CFD analysis. Future work is required to determine the optimal segmentation threshold.
采用计算流体动力学（CFD）方法对鼻气流进行客观分析有望带来巨大益处。在这个新兴领域，目前尚无关于鼻气道理想建模参数的标准。对于该工具在临床上具有相关性而言，此类标准将是必要的。
从一名健康对照者构建人类鼻气道模型，进行分割，并使用内部浸入边界方法进行分析。改变分割的亨氏单位（HU）阈值，以测量其对气流速度大小和压力变化的影响。
表面积和体积与HU阈值呈线性关系，而CFD变量的关系更为复杂。
HU阈值应纳入鼻气流CFD分析中。未来需要开展工作以确定最佳分割阈值。
