Hales M S, Miller T R
Acta Cytol. 1987 Jul-Aug;31(4):493-6.
Xanthogranulomatous cholecystitis is an uncommon benign thickening of the gallbladder wall characterized histopathologically by extensive histiocytic infiltration. A case is presented in which a 62-year-old woman with clinical cholecystitis was found at surgery to have a markedly thick-walled, adherent gallbladder, raising the differential diagnosis of an inflammatory versus an infiltrating neoplastic process. Intraoperative fine needle aspiration (FNA) biopsy revealed abundant foamy histiocytes ("xanthoma cells"), both dispersed and in clusters associated with capillaries suggestive of organization. Occasional multinucleated giant cells and columnar epithelial cells were also present. The differential diagnosis of histiocytic processes sampled by FNA biopsy is reviewed.
黄色肉芽肿性胆囊炎是一种罕见的胆囊壁良性增厚，组织病理学特征为广泛的组织细胞浸润。本文报告一例，一名62岁患有临床胆囊炎的女性在手术中发现胆囊壁明显增厚且粘连，这增加了炎症与浸润性肿瘤性病变的鉴别诊断难度。术中细针穿刺（FNA）活检显示有大量泡沫状组织细胞（“黄色瘤细胞”），既有散在分布的，也有与提示机化的毛细血管相关的细胞簇。还可见偶尔的多核巨细胞和柱状上皮细胞。本文对通过FNA活检取样的组织细胞病变的鉴别诊断进行了综述。
