Center for Cause of Death Investigation Research Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Department of Forensic Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Front Immunol. 2022 Aug 15;13:967226. doi: 10.3389/fimmu.2022.967226. eCollection 2022.
The global coronavirus disease 2019 (COVID-19) pandemic has led to the rapid development of vaccines against this disease. Despite the success of the international vaccination program, adverse events following vaccination, and the mechanisms behind them, remain poorly understood. Here we present four cases of death following receipt of a second dose of COVID-19 vaccine, with no obvious cause identified at autopsy. Using RNA sequencing, we identified genes that were differentially expressed between our post-vaccination cases and a control group that died of blood loss and strangulation. Three hundred and ninety genes were found to be upregulated and 115 genes were downregulated in post-vaccination cases compared with controls. Importantly, genes involved in neutrophil degranulation and cytokine signaling were upregulated. Our results suggest that immune dysregulation occurred following vaccination. Careful observation and care may be necessary if an abnormally high fever exceeding 40°C occurs after vaccination, even with antipyretic drugs.
全球 2019 年冠状病毒病（COVID-19）大流行导致针对这种疾病的疫苗迅速发展。尽管国际疫苗接种计划取得了成功，但疫苗接种后的不良反应及其背后的机制仍知之甚少。在这里，我们提出了 4 例接种第二剂 COVID-19 疫苗后死亡的病例，尸检未发现明显原因。使用 RNA 测序，我们确定了我们接种疫苗后的病例与死于失血和窒息的对照组之间差异表达的基因。与对照组相比，接种后病例中有 390 个基因上调，115 个基因下调。重要的是，参与中性粒细胞脱颗粒和细胞因子信号的基因上调。我们的结果表明，接种疫苗后发生了免疫失调。如果接种后出现异常高热（超过 40°C），即使使用退烧药，也可能需要仔细观察和护理。
