The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
Biomed Res Int. 2022 Aug 21;2022:6311419. doi: 10.1155/2022/6311419. eCollection 2022.
Polycystic ovary syndrome (PCOS) is the major reason for women's low fertility and the most frequent endocrine disorder in women of childbearing age. Homocysteine is an amino acid that contains sulfur that has been negatively correlated with the reproductive outcome of polycystic women treated with IVF/ICSI. However, the impact of blood homocysteine levels on the outcome of artificial insemination in polycystic ovary syndrome women is unknown. The goal of this study is to examine the impact of serum homocysteine on the result of intrauterine insemination in females who have polycystic ovary syndrome (PCOS).
96 infertile women (129 cycles) treated with artificial insemination were collected, including 66 cases (87 cycles) in the case group (PCOS group) and 30 cases (42 cycles) in the control group (male factor infertility). The differences in general data amongst two groups, such as BMI, Hcy, and age, were compared. The case group has been classified into two groups based on serum Hcy level: LHcy group (Hcy < 15) and HHcy group (Hcy ≥ 15). The relationship among pregnancy and serum Hcy level outcome in PCOS women was compared.
The PCOS group had substantially increased serum homocysteine levels in comparison to the control group ( = 0.019). Among PCOS women, the clinical pregnancy rates of artificial insemination in the HHcy group and LHcy group were 14.29% and 37.88%. The difference among the two groups was substantial ( = 0.044). Artificial insemination frequency, ovulation induction, BMI, infertility years, AMH, serum testosterone, HOME IR, TSH, TPOAb, hCG, daily follicle size, intimal thickness, and other factors did not differ greatly between the two groups.
Serum homocysteine levels are increased in women having PCOS. Their levels above the threshold will lower the clinical pregnancy rate of intrauterine insemination in PCOS women.
多囊卵巢综合征（PCOS）是女性低生育力的主要原因，也是育龄妇女最常见的内分泌紊乱。同型半胱氨酸是一种含硫的氨基酸，与接受 IVF/ICSI 治疗的多囊妇女的生殖结局呈负相关。然而，血液同型半胱氨酸水平对多囊卵巢综合征妇女人工授精结局的影响尚不清楚。本研究旨在探讨血清同型半胱氨酸对多囊卵巢综合征（PCOS）女性宫腔内人工授精结果的影响。
收集 96 例接受人工授精治疗的不孕妇女（129 个周期），其中病例组（PCOS 组）66 例（87 个周期），对照组（男性因素不孕）30 例（42 个周期）。比较两组一般资料[体质量指数（BMI）、同型半胱氨酸（Hcy）、年龄]差异。根据血清 Hcy 水平将病例组分为低 Hcy 组（Hcy<15）和高 Hcy 组（Hcy≥15），比较两组 PCOS 患者妊娠与血清 Hcy 水平的关系。
PCOS 组血清同型半胱氨酸水平明显高于对照组（ = 0.019）。在 PCOS 患者中，HHcy 组和 LHcy 组的人工授精临床妊娠率分别为 14.29%和 37.88%，两组差异有统计学意义（ = 0.044）。两组人工授精频率、促排卵、BMI、不孕年限、抗苗勒管激素、血清睾酮、HOMEIR、促甲状腺激素、甲状腺过氧化物酶抗体、绒毛膜促性腺激素、每日卵泡大小、内膜厚度等因素差异无统计学意义。
PCOS 患者血清同型半胱氨酸水平升高，其水平超过阈值会降低 PCOS 患者宫腔内人工授精的临床妊娠率。
