Sun Guojuan, Zhang Qiang, Liu Yi, Xie Ping
Ward Section of Home Overseas Doctors, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Maternity Rehabilitation Center, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
Appl Bionics Biomech. 2022 Aug 21;2022:6904769. doi: 10.1155/2022/6904769. eCollection 2022.
In complicated disorders like cancer, signaling pathways form a tangled network. Targeting one gene may result in an unfavorable reaction from another off-target gene. Such entwined complexities may result in treatment resistance or failure in cancer patients. The PI3K/Akt/mTOR (phosphoinositol 3-kinase/protein kinase B/mammalian target of rapamycin) pathway is dysregulated in cervical cancer and is used as a biomarker for therapy. PI3K is a kinase that consists of a regulatory and catalytic domain and has phosphorylation capability. Class I components like the catalytic part (PIK3CA and PIK3CD) and regulatory part (like PIK3R1, PIK3R2, PIK3R3, and PIK3R5) are associated with oncogenesis and growth factors in cervical cancer. This review is aimed at discussing the involvement of the PI3K component of the PI3K/Akt/mTOR network in cervical cancer. Specifically, class I catalytic subunit PIK3CA has been identified as a pharmacological target, making it therapeutically significant. Apart from discussing the function of PI3K and PIK3CA in cervical cancer, we also discuss their inhibitors, which may be beneficial in treating cervical cancer.
在诸如癌症等复杂疾病中，信号通路构成一个错综复杂的网络。靶向一个基因可能会导致另一个非靶向基因产生不良反应。这种错综复杂的情况可能导致癌症患者出现治疗抵抗或治疗失败。PI3K/Akt/mTOR（磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素哺乳动物靶蛋白）通路在宫颈癌中失调，并被用作治疗的生物标志物。PI3K是一种激酶，由一个调节结构域和一个催化结构域组成，具有磷酸化能力。I类成分，如催化部分（PIK3CA和PIK3CD）和调节部分（如PIK3R1、PIK3R2、PIK3R3和PIK3R5）与宫颈癌的肿瘤发生和生长因子有关。本综述旨在讨论PI3K/Akt/mTOR网络中的PI3K成分在宫颈癌中的作用。具体而言，I类催化亚基PIK3CA已被确定为一个药理学靶点，使其具有治疗意义。除了讨论PI3K和PIK3CA在宫颈癌中的功能外，我们还讨论了它们的抑制剂，这些抑制剂可能对治疗宫颈癌有益。
