吲哚衍生物的生物学研究。I. 2-氧代-3-吲哚基衍生物的合成及药理学研究。
Biological studies on indole derivatives. I. Synthesis and pharmacological studies of 2-oxo-3-indolyl derivatives.
作者信息
Khan M T, Ashraf M, Alam M, Lone K P
出版信息
Acta Physiol Pharmacol Latinoam. 1986;36(4):391-5.
PMID:3604703
Abstract
Two compounds, 3-hydroxy-3-acetonyl-oxindole (I) and compound 3-acetonylidene-oxindole (II) were synthesized by a convenient method, and their pharmacological/toxicological effects were studied in rabbit. These compounds produced transitory effects on serum enzymes. The cholesterol mobilizing effect is more prominent with compound (I).
摘要
通过一种简便方法合成了两种化合物，3-羟基-3-丙酮基-氧化吲哚（I）和3-亚丙酮基-氧化吲哚化合物（II），并在兔子身上研究了它们的药理/毒理作用。这些化合物对血清酶产生短暂影响。化合物（I）的胆固醇动员作用更为显著。
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