Scimonelli T, Celis M E
Acta Physiol Pharmacol Latinoam. 1986;36(4):431-7.
The present experiments were undertaken to examine the pattern of alpha-MSH during the estrous cycle in different hypothalamic areas and assess if during the whole estrous cycle the MSH which arises from proopiomelanocortin (POMC) has the same concentrations pattern as MSH from the dorso-lateral hypothalamus. MSH concentration of the mediobasal hypothalamus (MBH), preoptic area (POA) and dorso-lateral hypothalamus (DLH) was measured using a specific radioimmunoassay. The rats were sacrificed every four hours by perfusion. It is possible to observe a circadian rhythm in all the areas studied except in MBH during estrus. The MSH concentration in MBH was high during the light period, inversely, in POA the concentration remained low. In general, when MSH is high in MBH, it is low in POA and vice versa. The pattern of MSH in DLH is very similar to that observed for the peptide in POA.
进行本实验是为了研究不同下丘脑区域在发情周期中α-促黑素（α-MSH）的模式，并评估在整个发情周期中，源自阿黑皮素原（POMC）的MSH是否与来自下丘脑背外侧的MSH具有相同的浓度模式。使用特异性放射免疫分析法测量下丘脑内侧基底部（MBH）、视前区（POA）和下丘脑背外侧（DLH）的MSH浓度。每隔四小时通过灌注处死大鼠。除发情期的MBH外，在所研究的所有区域都可观察到昼夜节律。MBH中的MSH浓度在光照期较高，相反，POA中的浓度则保持较低。一般来说，当MBH中的MSH较高时，POA中的MSH较低，反之亦然。DLH中MSH的模式与POA中该肽的模式非常相似。
