Yuan Rui, Cui Xia, Liu Ping, Li Liping, Zhao Yao, Liu Xiaofeng
Dongcheng District Center for Disease Control and Prevention, Beijing 100009, China.
Beijing Center for Disease Control and Prevention, Beijing 100013, China.
Wei Sheng Yan Jiu. 2022 Jul;51(4):645-679. doi: 10.19813/j.cnki.weishengyanjiu.2022.04.024.
To explore the contamination characteristics of chloropropanol esters and glycidyl esters in infant formulas sold in Beijing in 2021, and to evaluate the exposure risk of chloropropanol esters and glycidyl esters for infants and toldders aged 0-36 months old.
The contents of chloropropanol esters and glycidyl esters in infant formula samples were determined using gas chromatography-mass spectrometry with deuterated internal standards. Combined with the recommended consumption of infant formulas, the exposure level of chloropropanol esters and glycidyl esters in infants and toddlers aged 0-36 months was calculated.
The detection rate of 3-chloropropane-1, 2-diol esters(3-MCPDE), 2-chloropropane-1, 3-diol esters(2-MCPDE) and glycidyl esters in infant formulas were 98.6%, 97.1% and 95.7%, respectively. The average contents of 3-MCPDE, 2-MCPDE and glycidyl esters were 44.54, 15.65 and 12.65 μg/kg. For infant of each age groups, the daily intakes of 3-MCPDE via infant formulas by each infant groups were 0.28-0.90 μg/(kg BW), which were all lower than the tolerable daily intake(TDI, 2 μg/(kg BW));the daily intakes of 2-MCPDE via infant formulas by each infant groups were 0.10-0.29 μg/(kg BW);the exposure levels of glycidyl were 0.08-0.22 μg/(kg BW), and the margin of exposure(MOE) values were all higher than 25 000.
Chloropropanol esters and glycidyl esters in infant formulas sold in Beijing from 2021 were less polluted and their intake was within the safe range.
探究2021年北京市售婴幼儿配方奶粉中氯丙醇酯和缩水甘油酯的污染特征，并评估0～36月龄婴幼儿对氯丙醇酯和缩水甘油酯的暴露风险。
采用气相色谱-质谱联用仪结合氘代内标法测定婴幼儿配方奶粉样品中氯丙醇酯和缩水甘油酯的含量。结合婴幼儿配方奶粉的推荐食用量，计算0～36月龄婴幼儿对氯丙醇酯和缩水甘油酯的暴露水平。
婴幼儿配方奶粉中3-氯-1,2-丙二醇酯（3-MCPDE）、2-氯-1,3-丙二醇酯（2-MCPDE）和缩水甘油酯的检出率分别为98.6%、97.1%和95.7%。3-MCPDE、2-MCPDE和缩水甘油酯的平均含量分别为44.54、15.65和12.65μg/kg。各年龄组婴幼儿通过婴幼儿配方奶粉摄入3-MCPDE的每日摄入量为0.28～0.90μg/（kg体重），均低于每日耐受摄入量（TDI，2μg/（kg体重））；各年龄组婴幼儿通过婴幼儿配方奶粉摄入2-MCPDE的每日摄入量为0.10～0.29μg/（kg体重）；缩水甘油酯的暴露水平为0.08～0.22μg/（kg体重），暴露边际（MOE）值均高于25000。
2021年北京市售婴幼儿配方奶粉中氯丙醇酯和缩水甘油酯污染程度较低，摄入量在安全范围内。
