妊娠高血压疾病患者血液和尿液中miR-101水平的诊断价值
Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy.
作者信息
Li Yushan, Wei Yuanyuan, Shao Jiong
机构信息
Department of Obstetrics and Gynecology, Jincheng People's Hospital, Jincheng, China.
出版信息
Clin Exp Hypertens. 2022 Sep 1:1-7. doi: 10.1080/10641963.2022.2110258.
OBJECTIVES
This study explored the miR-101 clinical significance in hypertensive disorder complicating pregnancy (HDCP).
METHODS
Pregnant women with gestational hypertension (GH)/mild preeclampsia (mPE)/severe preeclampsia (sPE) were included. The miR-101 levels were measured. Correlation between miR-101 and soluble fmslike tyrosine kinase-1 (sFlt-1), miR-101 predictive value, and factors influencing HDCP grade were evaluated.
RESULTS
Serum miR-101 was down-regulated and negatively correlated with sFlt-1. miR-101 was an independent risk factor for HDCP and decreased with HDCP severity. The area under the curve of miR-101 in differentiating GH from mPE and mPE from sPE was 0.7764 and 0.8529.
CONCLUSION
Serum miR-101 level may be a biomarker for grading HDCP.
目的
本研究探讨了miR-101在妊娠期高血压疾病（HDCP）中的临床意义。
方法
纳入患有妊娠期高血压（GH）/轻度子痫前期（mPE）/重度子痫前期（sPE）的孕妇。检测miR-101水平。评估miR-101与可溶性fms样酪氨酸激酶-1（sFlt-1）之间的相关性、miR-101的预测价值以及影响HDCP分级的因素。
结果
血清miR-101下调，且与sFlt-1呈负相关。miR-101是HDCP的独立危险因素，并随HDCP严重程度降低。miR-101区分GH与mPE以及mPE与sPE的曲线下面积分别为0.7764和0.8529。
结论
血清miR-101水平可能是HDCP分级的生物标志物。
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