干扰素调节因子 4 中的点突变 L116R 可差异化影响 Th2、Th9 和 Th17 细胞中的关键细胞因子产生。
Point mutation L116R in interferon-regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells.
机构信息
Institute of Medical Microbiology and Hospital Hygiene, Philipps-University Marburg, Marburg, Germany.
出版信息
Eur J Immunol. 2022 Oct;52(10):1680-1683. doi: 10.1002/eji.202249869. Epub 2022 Sep 19.
PMID:36047738
Abstract
IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction of Th9 cells in cells carrying the L116R mutated IRF4.
摘要
IRF4 敲除细胞不能正确分化为 T 辅助细胞亚群 2、9 和 17。与 WT IRF4 点突变 L116R 相比，显示出差异表达的关键细胞因子。虽然 Th2 和 Th17 细胞的数量减少，但携带 L116R 突变 IRF4 的细胞中 Th9 细胞的诱导作用很强。
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